OVERVIEW:

Synonyms	Monoclonal SMARCA4 antibody, Anti-SMARCA4 antibody, SMARCA-4 antibody, hSNF2b antibody, BAF190 antibody, SMARCA4, SNF2L4 antibody, SMARCA 4, SMARCA-4, SMARCA 4 antibody, SNF2-BETA antibody, SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 antibody, BRG1 antibody, SNF2LB antibody
Specificity	Human SMARCA4
Cross Reactivity	Human. Other species not studied
Applications	Dot Blot
Immunogen	SMARCA4 antibody was raised in mouse using recombinant Swi/Snf Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4 (Smarca4)

SPECIFICATIONS:

Host	Mouse
Clone	SMAR9G1F9
Isotype	IgG1
Method of Purification	SMARCA4 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer	SMARCA4 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration	100 ug/ml

STORAGE & SAFETY:

Storage	Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information	This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

Usage Assay Information:

Usage Recommendations	To be optimized by the end user.

GENERAL INFORMATION:

Biological Significance

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Multiple transcript variants encoding different isoforms have been found for this gene.

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