SGC707

1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea

Potent and selective allosteric inhibitor of proteinarginine methyltransferase 3 (PRMT3)¹. IC₅₀ = 31 nM and selective against 31 othermethyltransferases. An extremely useful probe for investigating the role ofPRMT3 in normal and pathophysiology. Cell permeable and active in vivo.

Physical Properties:Beige crystallinepowder; MP=233-235°C

MW=298.3 C₁₆H₁₈N₄O₂

Analysis:>98% (TLC);NMR (Conforms)

Solubilization:May be dissolvedin DMSO (35 mg/ml)

Storage:Store desiccated assupplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.

Amount: 5 mg