DESCRIPTION:Human recombinant BAZ2B bromodomain. In addition to a bromodomain, native BAZ2B comprises several other domains (DDT, PHD, MBD (methyl-CpG-binding domain)) that may interact with the DNA and histones of chromatin and its associated proteins, including chromatin remodeling complexes. The BAZ2B bromodomain binds various Lys(Ac) residues in singly acetylated histone peptide microarrays (histones H1.4, H2A, H2B, H3, H4) with binding to histone H3 K14(Ac) confirmed in solution by isothermal titration calorimetry (ITC). An allele of the BAZ2B locus shows an association with increased risk for sudden cardiac death.

SUPPLIED AS: Solution of purified recombinant protein in 50 mM HEPES, pH 7.0, 150 mM NaCl, 1 mM TCEP, 10 % glycerol

STORAGE: -70°C. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted enzyme is not recommended.

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Substantial Discounts Available on Bulk Quantities