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蚂蚁淘在线 / 品牌中心 / Adipogen / Adipogen/Splitomicin/AG-CR1-0088-M001/1 mg

Adipogen/Splitomicin/AG-CR1-0088-M001/1 mg

价格
￥500.00
货号：AG-CR1-0088-M001
浏览量：127
品牌：Adipogen
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Product Details
Synonyms Splitomycin; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one; 1-Naphthalen propanoic acid
Product Type Chemical
Properties
Formula C13H10O2
MW 198.2
CAS 5690-03-9
Purity Chemicals ≥98% (NMR)
Appearance White to off-white solid.
Solubility Soluble in methanol, ethanol or DMSO.
Identity Determined by 1H-NMR.
Other Product Data Handling Note: After reconstitution use immediately due to decomposition. We recommend to use fresh solutions. If you prepare aliquots store immediately at -20°C.
InChi Key ISFPDBUKMJDAJH-UHFFFAOYSA-N
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Keep cool and dry.
Keep under inert gas.
Protect from light and moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p [1-4].
  • Displays higher activity in vivo than in vitro [1-4].
  • Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket [5].
  • Shown to have diverse effects also in mammalian cells [6-10].
Product References
  1. Identification of a small molecule inhibitor of Sir2p: A. Bedalov, et al.; PNAS 98, 15113 (2001)
  2. Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast: M. Hirao, et al.; J. Biol. Chem. 278, 52773 (2003)
  3. Inhibitors of Sir2: evaluation of splitomicin analogues: J. Posakony, et al.; J. Med. Chem. 47, 2635 (2004)
  4. The Sir 2 family of protein deacetylases: J.M. Denu; Curr. Opin. Chem. Biol. 9, 431 (2005) (Review)
  5. Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53: I.A. Kim, et al.; Clin. Cancer Res. 12, 940 (2006)
  6. SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome: R. Biacsi, et al.; PLoS Genet. 4, e1000017 (2008)
  7. Splitomicin suppresses human platelet aggregation via inhibition of cyclic AMP phosphodiesterase and intracellular Ca++ release: F.C. Liu, et al.; Thromb. Res. 124, 199 (2009)
  8. Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells: M.R. Kang, et al.; Nucleic Acids Res. 38, 822 (2010)
  9. Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells: A. Breitenstein, et al.; Cardiovasc. Res. 89, 464 (2011)
  10. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival: U.H. Beier, et al.; Mol. Cell Biol. 31, 1022 (2011)
AdipoGen生命科学有限公司（AdipoGen）由两家公司组成，分别是Adipogen SA（瑞士）（及其分支机构Adipogen AG）和Adipogen Corporation（美国圣地亚哥）。公司总部位于美国圣地亚哥，而运营总部位于瑞士利斯塔尔。一支由高技能人士组成的积极团队，为肥胖和糖尿病，炎性疾病，先天免疫，免疫学，免疫肿瘤学，癌症，干细胞生物学和神经变性等领域的生命科学研究市场开发和制造新产品，以支持免疫代谢和高级炎症研究。除了抗体（特殊功能抗体）和蛋白质设施外，AdipoGen还拥有化学实验室，使该公司能够分离出独特的天然产物，并开发出创新的小分子和稀有抗生素。自2015年以来，AdipoGen在国际上以“ AdipoGen Life Sciences”品牌运营。除研究试剂外，AdipoGen还正在开发新产品，以在新的市场领域进行许可（临床诊断/治疗）。