Cryopreserved,Omental(1millioncells/vial),BMI>30.0

MetabolicdiseaseisassociatedmorecloselywiththeaccumulationofaBDominalADIposeinspecificvisceraldepots.Recentstudieshaveimplicatedomentalandmesentericadiposetissueinobesity-relatedinsulinresistance,atherosclerosis,andtype2diabetes.Toprovidethemostrelevantsystemsforinvestigatingobesity-relatedmorbidities,Zenbioisofferingvisceralderivedhumanpreadipocytesandculturedadipocytestotheresearchcommunity.

Preadipocytesareisolatedfromomental,mesenteric,orperirenaladiposetissueandaretestedfortheirABIlitytodifferentiateinculturetomatureadipocytes.Preadipocytesareavailablecryopreservedorplatedandmatureadipocytesareavailableinavarietyofplatedformats.

Mostcellsarederivedfromobesenon-diabeticpatients(BMI>30),buttherearelimitedquantitiesofpreadipocytesandadipocytesfrompatientsofBMI<27aswellassomelotsofcellsavailablefromdiabeticpatients.LotsderivedfrommultiplepatientsarealsoavailableasPooled-orSuper-lots.

Therearelimitedquantitiesofdonormatchedomentalandsubcutaneouspreadipocytesorculturedadipocytesforstudiescomparingthetwodepots.

OMENTALADIPOSE

Thegreateromentumisthelargestperitonealfoldwithintheabdomenandhasanimmunologicfunction.Theomentumaidsinisolatingperitonealinfectionandabsorbingcontaminantsthroughthemesothelialstomata.Adipokinesandfattyacidsfromthisdepothavedirectaccesstotheliverthroughtheportalcirculationwhichmayleadtohepaticdysfunction.

MESENTERICADIPOSE

Mesentericadiposelieswithinthethinlayersoftheperitonealmesotheliumconnectingthesmallandlargeintestine.Adiposeaccumulationwithinthisdepotcorrelateswithanincreasedriskofmetabolicdisease.

PERIRENALADIPOSE

Perirenaladiposeresidesnearthekidneysoutsidetheperitonealcavity.Fatfromthisdepothasnotbeencorrelatedwithincreasedriskformetabolicdisease.

Speciallyformulatedmediaareavailableforusewithouromentalpreadipocytesandadipocytes.

ZenBio提供了多种检测方法来检测作为潜在糖尿病或肥胖疗法的化合物。客户可以从以下任何一种检测方法中进行选择，或者我们可以设计一个针对每个客户的特定研究需求的定制程序。