快报
欢迎光临蚂蚁淘在线！ 请登录 免费注册
商品
品牌
文章
热门搜索：
快报
品牌首页 品牌新闻 品牌简介 产品中心 品牌咨询 联系我们
品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
蚂蚁淘在线 / 品牌中心 / StressMarq / 应力MARQ/1-磷酸鞘氨醇，D-红/SIH-386-1MG/1-mg

应力MARQ/1-磷酸鞘氨醇，D-红/SIH-386-1MG/1-mg

价格
￥2980.00
货号：SIH-386-1MG
浏览量：127
品牌：StressMarq
服务
全国联保
正品保证
正规发票
签订合同
商品描述

Overview:

ProductNameSphingosine-1-phosphate,D-erythro
Description

Signalingmolecule

Purity>98%
CASNo.26993-30-6
MolecularFormulaC18H38NO5P
MolecularWeight379.5

Properties

StorageTemperature-20ºC
ShippingTemperatureShippedAmbient
ProductTypeSecondMessenger
SolubilitySparinglysolublein1:1ethanol:water.Additionofsmallamountsofaceticacidmayhelpdissolvethisproduct.Solubleinwarmmethanol.
SourceSynthetic
AppearanceWhitesolid
SMILES[[email protected]@H](N)([[email protected]](O)C=CCCCCCCCCCCCCC)CO[P](=O)(O)O
InChIInChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
InChIKeyDUYSYHSSBDVJSM-KRWOKUGFSA-N
SafetyPhrasesClassification:Caution.Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-AvoidcontactwithskinandeyesHazardPhrases:H315-Causesskinirritation.H319-Causesseriouseyeirritation.H335-Maycauserespiratoryirritation.PrecautionaryPhrases:P261Avoidbreathingdust/fume/gas/mist/vapours/spray.P280Wearprotectivegloves/protectiveclothing/eyeprotection/faceprotection.P305+P351+P338IFINEYES:Rinsecautiouslywithwaterforseveralminutes.Removecontactlenses,ifpresentandeasytodo.ContinuerinsingP321Specifictreatment(seeonthislabel).P405Storelockedup.P501Disposeofcontents/containerinaccordancewithlocal/regional/national/internationalregulations
CiteThisProductSphingosine-1-phosphate,D-erythro(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-386)

BIOLOGicalDescription

AlternativeNames[(E,2S,3R)-2-Amino-3-hydroxyoctadec-4-enyl]dihydrogenphosphate
ResearchAreasCellSignaling
PubChemID5283560
ScientificBackgroundD-erythro-Sphingosine-1-phosphate(S1P)isapolarsphingolipidmetabolitewhichregulatesdiversecellularresponsesincludingcellgrowth,survivalandmigration.S1PwasreportedtostimulateDNAsynthesisandcelldivisioninquiescentculturesofSwiss3T3fibroblastsandtotriggerthedualsignaltransductionpathwaysofcalciummobilizationandPC-PLD(phospholipaseD)activation.S1PservesasasecondmessengerforintracellularcalciummobilizationinU-937cells(sc-2239)anddecreasescellularcAMP.RecentstudiesshowthatS1PisaG-protein-coupledreceptor(GPCR)ligandfortheEDG-1family,includingEDG-1,-3,-5,-6and-8.ThisbioactivelipidmediatorhasbeenshowntostimulatetheERKpathwayandtoalsocounteracttheceramide-inducedactivationofstress-activatedproteinkinase(SAPK/JNK).ResearchershavealsofoundthatS1PisastronginhibitorofcellmotilityandphagokinesisinB16melanomacells.Additionally,itinducesrapidandtransienttyrosinephosphorylationofepidermalgrowthfactorreceptor(EGFR)andc-Metingastriccancercells.S1Phasalsobeenknownasatumor-promotinglipid.SuggestedtobeanactivatorofGPR3,GPR6,andGPR12.D-erythro-Sphingosine-1-phosphateisanactivatorofEDG-1,EDG-3,EDG-2,EDG-4andEDG-5.¬
References1.VanVeldhovenP.P.,etal.(1989).J.LipidRes.30(4):611-6.
2.DesaiN.N.,etal.(1992).J.Biol.Chem.267(32):23122-8.
3.SadahiraY.,etal.(1992).Proc.Natl.Acad.Sci.U.S.A.89(20):9686-90.
4.OliveraA.andSpiegel,S.(1993).Nature.365(6446):557-60.
5.MattieM.,etal.(1994).J.Biol.Chem.269(5):3181-8.
6.WuJ.,etal.(1995).J.Biol.Chem.270(19):11484-8.
7.ChoiO.H.,etal.(1996).Nature.380(6575):634-6.
8.CuvillierO.,etal.(1996).Nature.381(6585):800-3.
9.SpiegelS.,etal.(2000).Biochim.Biophys.Acta.1484(2-3):107-16.
10.SpiegelS.andMilstien,S.(2000).FEBSLett.476(1-2):55-57.
11.Shida,D.,etal.(2004).FEBSLett.577(3):333-8.
12.Watterson,K.R.,etal.(2005).Cell.Signal.17(3):289-98.

ProductImages

<p>Chemical structure of Sphingosine-1-phosphate, D-erythro (SIH-386), a Endogenous signaling molecule. CAS #: 26993-30-6. Molecular Formula: C18H38NO5P. Molecular Weight: 379.5 g/mol.</p>

ChemicalstructureofSphingosine-1-phosphate,D-erythro(SIH-386),aEndogenoussignalingmolecule.CAS#:26993-30-6.MolecularFormula:C18H38NO5P.MolecularWeight:379.5g/mol.

ProductCitations(0)

Currentlytherearenocitationsforthisproduct.

StressMarq硫黄素T测定硫黄素T是一种荧光染料，可与富含β片层的结构（例如α突触核蛋白原纤维中的结构）结合。结合后，染料的发射光谱发生红移并增加了荧光强度。以下方案用于使用α突触核蛋白预制的原纤维和单体生成硫黄素T测定法。准备dH2O中的1mM硫黄素T储备溶液（新鲜制备，并通过0.2μm注射器过滤器过滤）。在PBS pH 7.4中稀释硫黄素T，使每孔中硫黄素T的最终浓度为25μM（每孔体积= 100μL）。板：Lumox 96多孔板（Sarstedt目录号94.6000.024）。使用前在室温下解冻α-突触核蛋白等分试样。将10μM预制纤维或100μM单体（或两者）添加到适当的孔中。用移液器上下吸取混合液。浓度是估算值，需要进行优化以给出良好的信号而不会造成浪费。密封板并置于37°C的振荡培养箱（600 rpm）中。使用Softmax Pro软件6.5.1版在Molecular Devices Gemini XPS微孔板读取器上测量荧光。 XPS微孔板读取器设置：温度：37°C读取类型：阱扫描波长：450 nm处的激发和485 nmPMT 处的发射增益：每次读取自动闪烁：6次摇动：读取前20秒7.重新密封板并放入37°C的振荡培养箱中。8.定期从1到72小时获取读数。