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0512-67156496
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商品描述
Overview:
| ProductName | 24(S)-Hydroxycholesterol |
| Description | LXRligand |
| Purity | >98% |
| CASNo. | 474-73-7 |
| MolecularFormula | C27H46O2 |
| MolecularWeight | 402.7 |
Properties
| StorageTemperature | -20ºC |
| ShippingTemperature | ShippedAmbient |
| ProductType | Ligand |
| Solubility | Solubleinethanol(10mg/ml)orDMSO(10mg/ml-requireswarmingupto~40°C). |
| Source | Synthetic |
| Appearance | Whitesolid |
| SMILES | [[email protected]]24([[email protected]]([[email protected]@H]1CC=C3[[email protected]@]([[email protected]]1CC2)(CC[[email protected]](O)C3)C)CC[[email protected]@H]4[[email protected]@H](CC[[email protected]@H](C(C)C)O)C)C |
| InChI | InChI=1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1 |
| InChIKey | IOWMKBFJCNLRTC-XWXSNNQWSA-N |
| SafetyPhrases | Classification:Caution.Substancenotyetfullytested.SafetyPhrases:S22-DonotbreathedustS36/37/39-Wearsuitableprotectiveclothing,glovesandeye/faceprotectionS24/25-Avoidcontactwithskinandeyes |
| CiteThisProduct | 24(S)-Hydroxycholesterol(StressMarqBiosciencesInc.,VictoriaBCCANADA,Catalog#SIH-384) |
BIOLOGicalDescription
| AlternativeNames | (3β,24S)-Cholest-5-ene-3,24-diol |
| ResearchAreas | CellSignaling |
| PubChemID | 121948 |
| ScientificBackground | EndogenousagoNISTforthenuclearreceptorLXR.Importantmetaboliteofcholesterolinthebrain.Displaysneurotoxiceffectsonhumanneuroblastomacells.Cerebrospinalfluidconcentrationsof24(S)-hydroxycholesterolareincreasedinpatientswithAlzheimer’sdiseaseandmildcognitiveimpairment. |
| References | 1.ChawlaA.,etal.(2001)Science.294(5548):1866-70. 2.LütjohannD.,etal.(1996)Proc.Natl.Acad.Sci.USA.93(18):9799-804. 3.KölschH.,etal.(1999)BrainRes.818(1):171-5. 4.SchönknechtP.,etal.(2002)Neurosci.Lett.324(1):83-5. 5.LeoniV.,etal.(2006)Neurosci.Lett.397(1-2):83-7. |
ProductImages
Chemicalstructureof24(S)-Hydroxycholesterol(SIH-384),aLXRligand.CAS#:474-73-7.MolecularFormula:C27H46O2.MolecularWeight:402.7g/mol.
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