Smartox/Apamin是一种SK通道阻断剂/08APA001-01000/1mg

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¥1560.00
货号:08APA001-01000
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品牌:Smartox
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商品描述

Apamin isaneurotoxinthatwasoriginallyisolatedfromApismellifera.Apaminbindstoandinhibitsthe SKchannels(smallconductanceCa2+-activatedK+ channels) inthebrainandspinalcord. Apamin inhibitsthreesubtypesof SKchannels(KCa2.1,KCa2.2,andKCa2.3) withdifferentaffinity. Apamin doesnotaffectKCa3.1channelactivity. Apaminmostlikelyactsasaporeblockersuchas Scyllatoxin or Tamapin,althoughresiduesbothinsideandoutsideoftheporeregionoftheSKchannelsparticipateinapaminbinding.TheSKchannelsarepresentinawiderangeofexcitableandnon-excitablecells,includingcellsinthecentralnervoussystem,intestinalmyocytes,endothelialcells,andhepatocytes.


Description:

Productcode:N/A.Category:KCachannels.Tags:24345-16-2,SK.

AAsequence: H-Cys1-Asn-Cys3-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys11-Ala-Arg-Arg-Cys15-Gln-Gln-His-NH2
Disulfidebonds: Cys1-Cys11 andCys3-Cys15
Length(aa): 18
Formula: C79H131N31O24S4
MolecularWeight: 2027.34Da
Appearance: Whitelyophilizedsolid
Solubility: waterandsalinebuffer
CASnumber: [24345-16-2]Source: Synthetic
Purityrate: >98%

Reference:

Apamin
HabermannE(1984).Apamin. PharmacolTher. PMID:6095335
Potassiumchanneltoxins

Manyvenomtoxinsinterferewithionchannelfunction.Toxins,asspecific,highaffinityligands,haveplayedanimportantpartinpurifyingandcharacterizingmanyionchannelproteins.Ourknowledgeofpotassiumionchannelstructureismeagerbecauseuntilrecently,nospecificpotassiumchanneltoxinswereknown,oridentifiedassuch.Thisreviewsummarizesthesuddenexplosionofresearchonpotassiumchanneltoxinsthathasoccurredinrecentyears.Toxinsarediscussedintermsoftheirstructure,physiologicalandpharmacologicalproperties,andthecharacterizationoftoxinbindingsitesondifferentsubtypesofpotassiumionchannels.

StrongPN(1990).Potassiumchanneltoxins. PharmacolTher. PMID:2181489

Toxinsinthecharacterizationofpotassiumchannels

Severalrecentlycharacterizedtoxins(apamin,charyBDotoxin,dendrotoxinandnoxiustoxin)areprovinginvaluableforestablishingwhatkindsofpotassiumchannelareexpressedinneurones,andwhattherolesofthechannelsmightbe.

CastleNA.etal.(1989).Toxinsinthecharacterizationofpotassiumchannels. TrendsNeurosci. PMID:2469212

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