ATTO488-ProTx-II is a fluorescently labeled ProTx-II, a famous Na_v1.7 blocker. The wild type ProTx-II blocks Na_v1.7  with an IC₅₀ value of around 300 pM, Na_v1.2,  Na_v1.5 and Na_v1.6 with IC₅₀ values of 41 nM, 79 nM and 26 nM respectively.

Description:

AA sequence: Tyr-Cys²-Gln-Lys-Trp-Met-Trp-Thr-Cys⁹-Asp-Ser-Glu-Arg-Lys-Cys¹⁵-Cys¹⁶-Glu-Gly-Met-Val-Cys²¹-Arg-Leu-Trp-Cys²⁵-Lys-Lys-Lys-Leu-Trp-OHDisulfide bonds: Cys²-Cys¹⁶, Cys⁹-Cys²¹, Cys¹⁵-Cys²⁵Length (aa): 30ProTx-II formula: C₁₆₈H₂₅₀N₄₆O₄₁S₈ProTx-II Molecular Weight: 3826,66 g/molSource: SyntheticPurity rate: > 95 %ATTO488: λ_ex 500nm , λ_em 520nmStoichiometry: 1:1

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