Description:

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains. RELIATech为在昆虫细胞（杆状病毒）和大肠杆菌中表达重组蛋白提供全面的客户服务。这些服务分为一系列步骤，可以单独执行或组合执行，以便您可以选择实际需要的步骤。这些服务旨在充分满足您的大多数需求，从将基因克隆到杆状病毒转移载体或大肠杆菌表达载体，重组杆状病毒或大肠杆菌菌株的产生到重组蛋白的生产和纯化。如果需要，我们还将尝试建立一种测定纯化蛋白的生物学活性的方法。