productdatasheet

CatalogNo.:1107

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

Signalsfrommostgrowthfactorsandcytokinesaretransducedbyreceptortyrosinekinasesornon-receptortyrosine

Antigen:Peptidecorrespondingtoaa425-439ofhumanp62dok.

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

kinases.Activatedtyrosinekinasesphosphorylatetheirsubstrateswhichmediatesthecellularresponsetoextracellularstimuli.Along-soughtmajorsubstratetermedp62dok(downstreamoftyrosinekinase)formanytyrosinekinases

Thisantibodyrecognizeshumanp62

(62kD).

Immunoblotting:useat1:1,000-1:2,000dilution.

dok

includingc-kit,v-abl,v-Fps,v-Src,v-Fms,andactivatedEGF,PDGF,IGF,VEGF,andinsulinreceptors,hasbeenidentifiedinhumanandmouse.Uponphosphorylation,

p62dokformsacomplexwiththeras

GTPase-activatingprotein(RasGAP).p62dok,alongwithp56dok,representsanewfamilyofRasGAP-bindingproteins.

Positivecontrol:WholecelllysateofJurkatcells.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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