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蚂蚁淘在线 / 品牌中心 / QED Bioscience / QED生物科学/CaMKII/56453/1 Ea

QED生物科学/CaMKII/56453/1 Ea

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￥7240.00

货号：56453

浏览量：127

品牌：QED Bioscience

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Anti-CaMKIIMonoclonalAntibody

ORDERINGINFORMATIONCatalogNo.:56453(clone6G9)Size:100uginPBS,pH7.4,purifiedbyProteinGaffinitychromatography.

BACKGROUND

CaMKII,amemberofthecalcium/calmodulin-activatedproteinkinasfamily,functionsinneuralsynapaticstimulationandT-cellreceptorsignaling.CaMKIIisexpressedinmanytissues,butitisspecificallyfoundintheneuronsoftheforebrain,anditsmRNAisfoundwithinthedendritesandthesomaoftheneuron.

CaMKIIinneuronsconsistsoftwosubunitsof52(alphagenes)and60kDa(betagenes).CaMKIIhascatalyticandregulatorydomainsaswellasanATP-bindingdomainandaconsensusphosphorylationsite.

Bindingofcalcium/calmodulintoitsregulatorydomainreleasesitsauto-inhibitoryeffectandactivatesthekinase.Thiskinaseactivationresultsinautophosphorylationatthreonine286.

AutophosphorylationconfersenhancedaffinityofCaMKIIforNMDAreceptorsinpostsynapticdensities.

SPECIFICATIONSUMMARYAntigen:PartiallypurifiedratCaMKIIHostSpecies:MouseAntibodyClass:IgG1Preservatives:0.09%sodiumazideOtheradditives:50%glycerolSPECIFICITY

Thisantibodyrecognizesthephosphorylatedandnon-phosphorylatedformsofmouse,rat,andbovineCaMKII.

APPLICATIONS

Immunoblotting:useat0.1-1ug/ml.Abandof~50-60kDaisdetected.

Immunohistochemistry:useat10ug/ml.

RIA:useat3-5ug/ml.

Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.

Positivecontrol:Ratbraintissueextract.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.