product data sheet

Anti-ESE-1 Polyclonal Antibody

ORDERING INFORMATION

Catalog No.: 34005

Size: 100 ug IgG in 100 ul (1 mg/ml) PBS.

BACKGROUND

Epithelium-specific gene regulation plays a critical role during embryogenesis, and the epithelial cell lineage is the first differentiated cell type to appear after fertilization. Until recently, very few epithelial cell-restricted transcription factors had been described. Members of the ets transcription factor/oncogene family have been implicated in human carcinogenesis following the discovery of several distinct chromosomal translocations involving members of the ets family in different types of cancer. ets factors play key roles in transcriptional control of stringently regulated genes, such as genes involved in tissue development, differentiation, angiogenesis, cell cycle control and cell proliferation. ESE-1 is the first member of the ets family that was found to be exclusively expressed and inducible in epithelial cells.

SPECIFICATION SUMMARY

Antigen: N-terminal sequence MAATCEISNIFSNYFS and C-terminal sequence SSGWKEEEVLQSRN of human ESE-1 protein.

Host Species: Rabbit

Preservatives: 0.02% sodium azide.

SPECIFICITY

This antibody recognizes human ESE-1 (39-41 kD).

APPLICATIONS

Immunoblotting: use at 1:500-1:1,000 dilution.

ELISA: use at 1:1,000-1:5,000 dilution.

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

This antibody is stable for at least one (1) year at -20oC. Avoid multiple freeze-thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

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