Anti-CAD (CT) Antibody

ORDERING INFORMATION

Catalog No.: 2011

Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

BACKGROUND

Cell death signals are transduced by death domain-containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (caspase activated deoxyribo- nuclease). Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.

SPECIFICATION SUMMARY

Antigen: Peptide corresponding to aa 314-329 of mouse CAD (accession no. O54788).

Host Species: Rabbit

Stabilizers: None

Preservatives: 0.02% sodium azide.

SPECIFICITY

This antibody recognizes full-length mouse CAD (40kDa).

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

APPLICATIONS

Immunoblotting: use at 1ug/ml.

Western blot analysis of CAD in murine lung (L) and kidney

(K) tissue lysates with CAD antibody at 1μg/ml.

Immunohistochemistry: use at 1ug/ml.

Immunohistochemical staining of CAD in mouse kidney tissue with CAD antibody at 1μg/ml.

These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

Positive control: Mouse lung or spleen tissue lysate.

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

This antibody is stable for at least one (1) year at -20oC. Avoid multiple freeze-thaw cycles.

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