product data sheet

Anti-Humanin Antibody

ORDERING INFORMATION

Catalog No.: 28106

Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma- tography.

BACKGROUND

Humanin is a secreted 24-aa polypeptide that specifically protects against neuronal cell death induced by beta-amyloid peptide or by mutations causing early-onset familial Alzheimer\'s disease. It does not affect cell death caused by Q79 or superoxide dismutase-1.

SPECIFICATION SUMMARY

Immunogen: Synthetic peptide corresponding to amino acids 9-24 (LLLLTSEIDLPVKRRA) of human

Humanin conjugated to KLH at the N- terminus.

Host Species: Rabbit

Stabilizers: None Preservatives: None. Available on request.

SPECIFICITY

This antibody recognizes human Humanin conjugated to carrier proteins, as free polypeptide, and as a fusion protein.

APPLICATIONS

Immunoblotting : use at 1:500 dilution. Positive control: synthetic peptide or transfected cell lysate.

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

This antibody is stable for at least one

(1) year at -20oC. Avoid multiple freeze- thaw cycles.

BACKGROUND REFERENCE

Hashimoto,Y. et al. ( 2001) Proc Natl Acad Sci USA 98:6336-41.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

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