Prospec/SHBG Human/PRO-1603/10µg

价格
¥2600.00
货号:PRO-1603
浏览量:80
品牌:Prospec
服务
全国联保
正品保证
正规发票
签订合同
商品描述

Catalogue number

PRO-1603

Synonyms

Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, Testis-specific androgen-binding protein, ABP, Testosterone-estradiol-binding globulin, TeBG, Testosterone-estrogen-binding globulin, SHBG.

Introduction

Sex-hormone-binding globulin (SHBG) is a beta-globulin which specifically binds steroid hormones; it is involved in the transport of sex steroids in plasma. The main site of SHBG synthesis is assumed to be the hepatocytes. The production of SHBG is regulated by androgen/estrogen balance, thyroid hormones, insulin and dietary factors, among others. The concentration of SHBG is a key factor regulating their distribution between protein-bound and free states. SHBG concentration determination is primarily significant in the evaluation of mild disorders of androgen metabolism and it allows detection of women with hirsutism who are likely to react to estrogen therapy. Testosterone/SHBG-ratios correlate well with both measured and calculated values for free testosterone thus aid to distinguish between subjects with excessive androgen activity and normal individuals. SHBG gene polymorphisms are linked with polycystic ovary syndrome and type 2 diabetes mellitus.

Description

SHBG Human Recombinant produced in CHO cells is a single, glycosylated, polypeptide chain containing a total of 428 amino acids, having a molecular mass of 46.79kDa (calculated), the SHBG is fused to a 6 a.a C-terminal His tag and also includes a myc-epitope.
The Human SHBG is purified by proprietary chromatographic techniques.

Source

CHO cells.

Physical Appearance

Filtered colorless solution.

Formulation

SHBG filtered (0.4 µm) solution at a concentration of 1mg/ml in certified FBS (Fetal Bovine Serum).

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Amino acid sequence

AAQPARRARR TKLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA GPRLDDGRWH QVEVKMEGDS VLLEVDGEEV LRLRQVSGPL TSKRHPIMRI ALGGLLFPAS NLRLPLVPAL DGCLRRDSWL DKQAEISASA PTSLRSCDVE SNPGIFLPPG TQAEFNLRDI PQPHAEPWAF SLDLGLKQAA GSGHLLALGT PENPSWLSLH LQDQKVVLSS GSGPGLDLPL VLGLPLQLKL SMSRVVLSQG SKMKALALPP LGLAPLLNLW AKPQGRLFLG ALPGEDSSTS FCLNGLWAQG QRLDVDQALN RSHEIWTHSC PQSPGNGTDA SHSRGGPEQKLISEEDLNSA VDHHHHHH.

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
ProSpec的生产和研发工厂位于以色列雷霍沃特(Rehovot),专注于蛋白(重组及合成)生产研发。目前ProSpec可以提供细胞因子,生长因子,激 素,信号蛋白,病毒抗原等近800种重组蛋白和100多种抗体,是世界上提供蛋白品种最多的公司之一,领先的生产工艺和规模使其可以提供毫克到克级蛋白, 价格优于同类公司。    欢迎各位ProSpec客户及合作伙伴拨打全国免费电话 400-6800-868转801/802/803 垂询蚂蚁淘科技 问询相关产品及解决方案!   代理ProSpec细胞因子、生长因子、激素、病毒抗原等重组蛋白产品简介 为便于客户选购ProSpec公司的各种重组蛋白,特将选购及使用注意事项列举如下:   1、需要考虑细胞因子、生长因子的种属来源和表达细胞选择 ProSpec可以提供多种不同种属来源的细胞因子等重组蛋白,如白介素-3,可以提供 人白介素-3、小鼠白介素-3、大鼠白介素-3;而瘦蛋白Leptin则有人源、小鼠源、大鼠源、 绵羊源、猪源、河豚源、马源、鸡源、狗源、兔源等十多种不同Leptin。蚂蚁淘科技推荐,建议按照作用的细胞选择相同种属的细胞因子。不过不同种属之间,蛋白同源性(序列一致性)在80%以上的基本上就可确定为有交叉活性,可推荐使用。另外,蚂蚁淘还可以向您提供ProSpec不同种属细胞表达的细胞因子,以重组人血管内皮生长因子(rVEGF)为例,ProSpec可以提供大肠杆菌表达的、酵母Yeast表达的、中国仓鼠卵巢CHO细胞、人胚肾HEK细胞表达的VEGF。可以根据您的实验需求,垂询蚂蚁淘科技有限公司为您推荐不同细胞表达的细胞因子产品。   2、ProSpec细胞因子的溶解和保存建议   ProSpec绝大部分细胞因子产品是天然成熟型蛋白,而不含有载体蛋白(Carrier Protein)或其他添加剂(如BSA、HAS或蔗糖等)。同时,ProSpec-Tany绝大部分产品通常以最少量的盐来进行冻干处理,因此易于运输 和保存。所以我们建议在收到产品后,务必在开盖前先离心,使粘在管盖或管壁上的蛋白聚集于管底(此时能否见到白色沉淀均属正常现象)。为获得更好生物活性 和保存稳定性,请联系蚂蚁淘科技垂询相关的溶解以保存建议。   领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司,而小包装形式的细胞因子也受广大研究生客户喜爱。作为ProSpec的中国总代理,蚂蚁淘科技有限公司为客户精选真核细胞表达、高活性的几十多种常用现货ProSpec细胞因子。更多细胞因子产品请查询蚂蚁淘网站或垂询蚂蚁淘科技有限公司。