神经组学/VEGF-C/PR27170-1000/1mg

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¥55980.00
货号:PR27170-1000
浏览量:127
品牌:Neuromics
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Type:Protein

 

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

VEGF-C,alsoknownasVascularEndothelialGrowthFactorRelatedProtein(VRP),isarecentlydiscoveredVEGFgrowthfactorfamilymemberthatismostcloselyrelatedtoVEGF-D.HumanVEGF-CCDNAencodesapre-pro-proteinof416aminoacidsresidues.ItisalmostidenticaltothemouseVEGF-Cprotein.SimilartoVEGF-D,VEGF-ChasaVEGFhomologydomainspanningthemiddlethirdoftheprecursormoleculeandlongN-andC-terminalextensions.Inadults,VEGF-Cishighlyexpressedinheart,placenta,ovaryandsmallintestine.

RecombinanthumanVEGF-C,lackingtheN-andC-terminalextensionsandcontainingonlythemiddleVEGFhomologydomain,formsprimarilynon-covalentlylinkeddimers.ThisproteinisaligandforbothVEGFR-2/KDRandVEGFR-3/FLT-4.SinceVEGFR-3isstronglyexpressedinlymphaticendothelialcells,ithasbeenpostulatedthatVEGF-Cisinvolvedintheregulationofthegrowthand/ordifferentiationoflymphaticendothelium.AlthoughrecombinanthumanVEGF-Cisalsoamitogenforvascularendothelialcells,itismuchlesspotentthanVEGF-A.Itisalsoapotenttrophicfactorforneuralstemcells. see-doi:10.1038/nn1646.

Note:ThisVEGF-C isfullybiocativeasMeasuredbyitsABIlitytobindtotheVEGFR-3/FLT-4receptorintheBa/F3-hVEGFR-3assay.TheED50inthisassayisabout4ng/mlcorrespondingtoaSpecificActivityof250,000IU/mg.

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