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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
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https://www.ebiomall.com
商品描述
Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllAITRLprotein,alsoknownasTNFSF18orOsteostat,is detectableinhumanmicrovascularECandishighlyup-regulatedbyIFN-alphaandIFN-beta.
AITRLinhibitsdifferentiationofosteoclastsfrommonocyticprecursorcells. Italsosuppressestheearlystageofosteoclastogenesisviainhibitionofmacrophagecolony-stimulatingfactorinducedreceptoractivatorofNF-kappaB(RANK)expressionintheosteoclastprecursorcells. Itdoesnotinhibitlipopolysaccharide-inducedRANKexpressioninmonocytesanddendriticcells,oractivation-inducedRANKexpressioninTcells. AITRLisanovelregulatorofosteoclastgenerationandsubstantiatethemajorroleplayedbytheendotheliuminbonephysiology.
