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T1/ST2(alsoknownasIL-1R4orIL-33Ra)isatransmembraneglycoproteinexpressedonmastcellsandTh2cells.ItisaselectiveMarkerforbothmurineandhumanTh2lymphocytesandplaysaroleinregulatinginflammatoryresponses.IL-33isarecentlyidentifiedmemberoftheIL-1familyofcytokinesandisinvolvedinTh2mediatedimmuneresponses.IL-33mediatesitsBIOLOGicaleffectsviaT1/ST2binding.TherolesofIL-33andT1/ST2(IL-33Ra)havebeeninvestigatedinmanyimmuneresponsessuchasallergy,asthma,rheumatoidarthritisandosteoarthritis.
Ratanti-MouseT1/ST2PE-conjugatedmAb
Clone:DJ8
IgSubclass:IgG1(lightchainnotisotyped)
Form:TheR-phycoerthrinfreeBovineSerumAlbumin(BSA)andwith0.1%sodiumazideasaperservativeandpurifiedoverproteinG-sepharose.ThecharacteristicsofeachlotaretestedbyFACSanalysiswithbone marrowderivedmastcells.
Specificity:ThisclonerecognizesthemembraneanchoredmurineT1MproteinonthesurfaceofThelper 2cellsandmastcells.T1MappearsonfetalbloodderivedmastcellProgenitorsbeforethey expresstheFceRI,onIL-3-dependentbonemarrowderivedmastcellsandonmatureperitoneal mastcells.TheantibodydetectsT1Sproteinconsistingonlyoftheextracellularportionof theprotein,whichissecretedfromgrowthfactorandproinflammatorycytokine-stimulated murinefibroblasts.
Immunogen:EukarioticallyexpressedfusionproteinofmouseT1ectodomainandhumanimmunoglobulin Fcdomain.
How_To_Use:
ThisantibodyallowstheidentificationandpurificationofmurineThelper2cellsandallforms ofmurinemastcells.
Applications
- Flowcytometry
- immunoprecipitation
MD Bioproducts的ELISA法目录编号名称数量/尺寸M036005N小鼠OVA-IgE ELISA96口井M046006酶联免疫吸附测定96口井M046008Aggrecanase活性ELISA96口井M046009Aggrecanase活性,灵敏的ELISA96口井M046010降钙素ELISA96口井M056011内啡肽(β-Endorphin)ELISA96口井M046013EPO ELISA96口井M046043HtrA丝氨酸肽酶-1(HtrA1)ELISA,人类96口井M056014亮氨酸-脑啡肽酶联免疫吸附测定96口井M046015MMP-13(活化)ELISA96口井M046016PTH,完整ELISA96口井M056018P物质ELISA96口井


