DESCRIPTION:

Afullyvalidated,highlyspecificaffinitypurifiedrabbitpolyclonalantibodytoSerine-2814phosphorylatedRyanodineReceptor

TheRyanodineReceptor(RyR2)isaCa2+channelofcardiacmusclethatplaysacentralroleinECcoupling.ThebindingofCa2+toryanodinereceptor2RyR2opensthechannelandCa2+storedintheSRmovesthroughthechannelintothecytosoltoinitiatemusclecontraction.CaMKII,wasabletophosphorylateSer-2814ofRYR2enhancingCa2+-sensitivityandincreasingopenprobABIlity.ExcessivephosphorylationofSer-2814leadstoatrialfibrillation,arrhythmiasandsuddendeath.

Testedapplications:Westernblot(1:1000dilution). Speciesrecognition:Allmammalianspecies,whenphosphorylatedonSer-2814(orSer-2815rabbit). 

DATASHEET:

Description	LyophilisedrabbitpolyclonalIgGantibody(A010-31AP)specifictoRyR2phosphoser-2814
Immunogen	Syntheticpeptide(TSQVS(PO3H2)VDAAH2819)correspondingtoaminoacidssurroundingthephosphorylatedserineresidueatposition2814ofRyR2(human)conjugatedtoKLH.
Isotype	IgG
Purification	ProteinAaffinitypurified
Speciesreactivity	Dog,mouse,human:despiteminordifferencesinsequence,thisantibodyinteractswithantigenbasedonthehumanandmousesequence.
Testedapplications	WB.Notyettestedinotherapplications,therefore,optimaldilutions/concentrationsshouldbedeterminedbytheuser.AlsoeffectiveinELISAandIHCmicroscopy.
Recommendeddilution	WB1:1000
Optimization	Optimaldilutionstobedeterminedbyenduser
Storage	Lyophilisedantibodyisstableat4°Cwhenstoredwithdesiccant.Reconstitutelyophilisedpowderin100µlof18MΩH2O,aliquotandstorefrozenat-80°Cfor1year.Avoidfreeze-thawcycles.
Storage	Lyophilised:4°CReconstituted:-80°C
Datasheet	A010-31APLot0611-03 A010-31APLot0314-01
MSDS	A010-31AP>
Regulatorystatement	Productforresearchuseonly.Notintendedfordiagnosticortherapeuticuse.

badrilla公司是一个生命科学公司。主要为制药，生物分子的心血管研究人员提供高质量的产品，并在全球学术机构。badrilla帮助研究人员结合其精细有机蛋白的蛋白质，协调心肌兴奋收缩耦联的翻译后修饰的化学专业知识，心律失常和肥大，和不良反应导致心脏衰竭，以产生最高的完整的研究工具和广泛的应用。