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蚂蚁淘在线 / 品牌中心 / Alomone / 阿洛蒙/抗腺苷A3受体抗体/AAR-004/50µl

阿洛蒙/抗腺苷A3受体抗体/AAR-004/50µl

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￥7340.00

货号：AAR-004-50µl

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品牌：Alomone

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商品描述

Cat#:AAR-004

LyophilizedPowder

AntigenIncl.

ShippedatRoomTemp.

Type:Polyclonal

Source:Rabbit

Reactivity:h,r

Mayalsoworkin:m

Immunogen

Peptide(C)KETGAFYGREFKTAK,correspondingtoaminoacidresidues216-230ofhumanA₃AR(AccessionP0DMS8).3^rdintracellularloop.

Accession(Uniprot)NumberP0DMS8

GeneID140

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyRat,mouse -14/16aminoacidresiduesidentical.

PurityAffinitypurifiedonimmobilizedantigen.

FormulationLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution25μl,50μlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.

Antibodyconcentrationafterreconstitution0.7mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).

ControlantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.

Controlantigenreconstitution100µldoubledistilledwater(DDW).

Controlantigenstorageafterreconstitution-20°C.

PreadsorptionControl1μgpeptideper1μgantibody.

StandardqualitycontrolofeachlotWesternblotanalysis.

Applications:ic,ih,wb

Mayalsoworkin:ifc,ip

Westernblot

WesternblotanalysisofMalme-3Mcelllysate:

1.Anti-Adenosine A₃ ReceptorAntibody(#AAR-004),(1:200).
2.Anti-AdenosineA₃ ReceptorAntibody,preincubatedwiththecontrolpeptideantigen.

Immunohistochemistry

Anti-Adenosine A3 Receptor Antibody - Expression of Adenosine A3 Receptor in rat lung

ExpressionofAdenosine A₃ Receptorinratlung

Immunohistochemicalstainingofparaffin-embedded ratlungsectionsusingAnti-Adenosine A₃Receptor Antibody(#AAR-004),(1:50).Stainingisspecificforrespiratoryepithelialcellsofthebronchiole(arrows)andpneumonocytesinthealveolarwall(a).Hematoxilinisusedasthecounterstain.

Immunocytochemistry

Anti-Adenosine A3 Receptor Antibody - Expression of Adenosine A3 Receptor in a human melanoma cell line

ExpressionofAdenosine A₃ Receptorinahumanmelanomacellline

Immunocytochemicalstainingofparaformaldehyde-fixedandpermeABIlized humanmelanomacells(A2058).A,D.CellswerestainedusingAnti-Adenosine A₃Receptor Antibody(#AAR-004),(1:100),followedbygoatanti-rabbitAlexaFluor-555secondaryantibody.B,E.Nuclearfluorescencestainingofcellsusingthemembrane-permeableDNAdyeHoechst33342.C.MergedimageofpanelsAandB.F.MergedimageofpanelsDandE.

References

Okusa,M.D.(2002)Am.J.Physiol.RenalPhysiol.282,F10.
Fredholm,B.B.etal.(2001)Pharmacol.Rev.53,527.
Nakata,H.(1989)J.Biol.Chem.264,16545
Baraldi,P.G.etal.(2006)Curr.Med.Chem.13,3467.
Headrick,J.P.etal.(2003)Am.J.Physiol.HeartCirc.Physiol.285,H1797.
MADI,L.etal.(2004)Clin.CancerRes.10,4472.
Ochaion,A.etal.(2007)Ann.Rheum.Dis.66,446.

Scientificbackground

Adenosineisanendogenousnucleosidegeneratedlocallyintissuesunderconditionsofhypoxia,ischemia,orinflammation.Itmodulatesavarietyofphysiologicalfunctionsinmanytissuesincludingthebrainandheart.^1,2 Adenosineexertsitsactionviafourspecificadenosinereceptors(alsonamedP1purinergicreceptors):AdenosineA₁ Receptor (A₁AR), AdenosineA_2A Receptor (A_2AAR),AdenosineA_2B Receptor (A_2BAR),and AdenosineA₃ Receptor (A₃AR).Thevariousadenosinereceptorscanbedistinguishedonthebasisoftheirdistinctmolecularstructures,distincttissuedistributions,anddifferentialselectivityforadenosineanalogs.^1-4 AllareintegralmembraneproteinsandaremembersoftheGprotein-coupledreceptorsuperfamily.Theyshareacommonstructureofsevenputativetransmembranedomains,anextracellularaminoterminus,acytoplasmiccarboxylterminus,andathirdintracellularloopimportantinbindingGproteins.^1-3

ExpressionofA₃ARhasbeenreportedinthebrain,kidney,liver,andheart.Itplaysaroleinmodulationofcerebralischemia,asthma,andcellgrowth.Inaddition,recentstudieshaveestablishedacardioprotectiveroleforA₃AR.⁵ ExpressionofA₃ARwasreportedtobeelevatedincanceroustissuesaswellasinauto-immuneinflammatorydiseases.^6,7 ApatenthasbeenfiledfortheuseofA₃ARandA₃ARagoNISTasadiagnosticMarkerfortherapeutictreatmentsofcancerandotherdiseases.

LyophilizedPowderControlAntigenIncluded

Clickheretoreceivea25µlfreetrialsample!

Lastupdate:26/02/2019

AlomoneLabsispleasedtoofferahighlyspecificantibodydirectedagainstanintracellularepitopeofthehumanadenosineA₃ receptor(A₃AR).Anti-Adenosine A₃ReceptorAntibody(#AAR-004)canbeusedinwesternblotanalysis,aswellasimmunocytochemicalandimmunohistocemicalapplications,andhasbeendesignedtorecognizeA₃ARfromhuman,rat,andmousesamples.

Forresearchpurposesonly,notforhumanuse

Westernblot

WesternblotanalysisofMalme-3Mcelllysate:

1.Anti-Adenosine A₃ ReceptorAntibody(#AAR-004),(1:200).
2.Anti-AdenosineA₃ ReceptorAntibody,preincubatedwiththecontrolpeptideantigen.

Alomone Labs是您离子通道研究的合作伙伴，是离子通道，GPCR和神经信号工具的领先供应商。我们专门生产基础科学研究中使用的一抗，小分子，蛋白质和肽。Alomone成立于1989年，现已成为全世界科学家使用的最全面的离子通道研究工具来源。Alomone的所有产品均经过生物测定验证，并以冻干粉形式提供，因此您可以对它们的生物活性和长保质期充满信心。立即索取信息 Alomone公司作为世界上***的离子通道专业供应商，它的离子通道抗体是世界上*全的、质量也非常好！目前被世界各地的科学家广泛的使用. Alomone Labs Alomone 公司是一家位于耶路撒冷的以色列著名的生物科技公司，专著于提供生命科学细胞生物学试剂和服务。Alomone 公司作为世界上最著名的离子通道专业供应商，它的离子通道抗体是世界上最全的、质量也非常好！目前被世界各地的科学家广泛的使用。试剂

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阿洛蒙/抗腺苷A3受体抗体/AAR-004/50µl

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