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蚂蚁淘在线 / 品牌中心 / Absolute Antibody / absoluteantibody/Ab00940-10.0 Anti-Envelope protein (soluble) [Z3L1]/Ab00940-10.0/ 200 µg
商品描述
Description:RecombinantmonoclonalantibodytoEnvelopeprotein(soluble).ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromtheB-cellcloneZ3L1.
SpeciesandIsotype:HumanIgG1,lamBDa
CloneNumber:Z3L1
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):NTRL;crystallisation;ELISA;FC;SPR
PublishedSpeciesReactivity:Zikavirus
Immunogen:Anti-ZIKVmAbswereobtainedfromtheseraandperipheralbloodmononuclearcellsofaZIKV-infectedpatient.
Specificity:Z3L1bindstotheZIKVsolubleenvelope(sE)protein,shownusingSPR,kineticcompetitionassaysandcrystallography(Wangetal,2016).ThismAbishighlyspecificforZIKV,andwasshowntoexhibitnoneutralisationactivityagainstDENV-1toDENV-4virions,whicharehighlyrelatedtoZIKV.ItwasshowncrystallographicallythattheZ3L1FabregionbindstodomainIanddomainIIofsE.ZIKVhasrecentlybecomeamajorglobalhealthconcern,followinga2015outbreak.Viralinfectionisassociatedwithneurologicalcomplicationsandmicroencephaly.
ApplicationNotes:Z3L1wasconfirmedtobindZIKVsEproteinbyELISA,withanaffinityof5.39uMshownbySPR(Wangetal,2016).UsingaFACS-basedassay,itwasshownthatZ3L1wassufficientforcompleteneutralisationofviralactivityagainstinfectedC6/36andVerocells.Invivo,ithasbeenshownthatZ3L1protectedIFNreceptorKOmicefromZIKVinfection.
AntibodyFirstPublishedin:
Wangetal.MoleculardeterminantsofhumanneutralizingantibodiesisolatedfromapatientinfectedwithZikavirus.SciTranslMed.2016Dec14;8(369):369ra179.Noteonpublication:Describestheidentificationofseveralanti-ZIKVmAbsfromthebloodofapatientwithZIKVinfection.ThemAbsidentifiedwerecharacterisedforantigenspecificityusingbiochemicalandbiophysicalmethods,andafewofthemAbsfoundwerecrystallisedwiththeZIKVsEprotein.
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司，可以在两周内提供100mg级的工程化抗体，并且没有动物成分，批间差很小，消除因补体和Fc受体造成的背景，使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。 SpeciesandIsotype:HumanIgG1,lamBDa
CloneNumber:Z3L1
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):NTRL;crystallisation;ELISA;FC;SPR
PublishedSpeciesReactivity:Zikavirus
Immunogen:Anti-ZIKVmAbswereobtainedfromtheseraandperipheralbloodmononuclearcellsofaZIKV-infectedpatient.
Specificity:Z3L1bindstotheZIKVsolubleenvelope(sE)protein,shownusingSPR,kineticcompetitionassaysandcrystallography(Wangetal,2016).ThismAbishighlyspecificforZIKV,andwasshowntoexhibitnoneutralisationactivityagainstDENV-1toDENV-4virions,whicharehighlyrelatedtoZIKV.ItwasshowncrystallographicallythattheZ3L1FabregionbindstodomainIanddomainIIofsE.ZIKVhasrecentlybecomeamajorglobalhealthconcern,followinga2015outbreak.Viralinfectionisassociatedwithneurologicalcomplicationsandmicroencephaly.
ApplicationNotes:Z3L1wasconfirmedtobindZIKVsEproteinbyELISA,withanaffinityof5.39uMshownbySPR(Wangetal,2016).UsingaFACS-basedassay,itwasshownthatZ3L1wassufficientforcompleteneutralisationofviralactivityagainstinfectedC6/36andVerocells.Invivo,ithasbeenshownthatZ3L1protectedIFNreceptorKOmicefromZIKVinfection.
AntibodyFirstPublishedin:
Wangetal.MoleculardeterminantsofhumanneutralizingantibodiesisolatedfromapatientinfectedwithZikavirus.SciTranslMed.2016Dec14;8(369):369ra179.Noteonpublication:Describestheidentificationofseveralanti-ZIKVmAbsfromthebloodofapatientwithZIKVinfection.ThemAbsidentifiedwerecharacterisedforantigenspecificityusingbiochemicalandbiophysicalmethods,andafewofthemAbsfoundwerecrystallisedwiththeZIKVsEprotein.
ProductForm
Purification:ProteinAaffinitypurifiedSuppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
