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蚂蚁淘在线 / 品牌中心 / Absolute Antibody / 绝对抗体/Ab00337-6.4抗视紫红质[Rho 1D4]/Ab00337-6.4/200µg

绝对抗体/Ab00337-6.4抗视紫红质[Rho 1D4]/Ab00337-6.4/200µg

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￥5400.00
货号：Ab00337-6.4
浏览量：127
品牌：Absolute Antibody
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商品描述
Description:RecombinantmonoclonalantibodytoRhodopsin.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaRho1D4.ThisantibodywascreatedusingourproprietaryFcSilent™engineeredFcdomaincontainingkeypointmutationsthatabrogatebindingtoFcgammareceptors.
SpeciesandIsotype:RatIgG1,FcSilent™,kappa
CloneNumber:Rho1D4
UniProtAccessionNumberofTargetProtein:P08100
AlternativeName(s)ofTarget:VisualPurple
PublishedApplication(s):RADIoimmunelabeling;WB;ELISA;IP;IF;IHC
PublishedSpeciesReactivity:Mouse;Rat;Cow;Human,Zebrafish,Amphibians
Immunogen:Bleachedbovinerodoutersegment(ROS).
Specificity:TheantibodybindstotheC-terminusofrhodopsinonthecytoplasmicsideofdiskmembranes.Theepitopehasthefollowingaminoacidsequence:"TETSQVAPA".Alimitationofthe1D4tag,however,isthatithastobeplacedattheC-terminusofaprotein.ThisisbecausetheRho1D4monoclonalantibodyrequiresafreecarboxylategroupforhighaffinitybinding.AmidationofthecarboxylgrouplowersitsimmunoreactivitytotheRho1D4antibodybyover100fold.
ApplicationNotes:TheantibodybindstotheC-terminusofrhodopsinonthecytoplasmicsideofdiskmembranes.RhodopsinisthemajorpigmentinrodphotoreceptorsandbelongstothefamilyofG-protein-coupledreceptors(GPCRs).Thelinearepitope(TETSQVAPA)canbeusedasaproteintag.
AntibodyFirstPublishedin:
Moldayetal.1983Monoclonalantibodiestorhodopsin:characterization,corss-reactivity,andapplicatoinassturcturalprobes.Biochemistry,1983;22(3):653-660PMID:6188482Noteonpublication:Describesthegenerationoftwomonoclonalantibodiesfromhybridoma.

ProductForm

Purification:ProteinAaffinitypurified
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.

Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody英国牛津大学Hutchings博士和Barclay教授创办的第二代抗体公司，可以在两周内提供100mg级的工程化抗体，并且没有动物成分，批间差很小，消除因补体和Fc受体造成的背景，使结果更干净。该公司的成立顺应了Nature杂志为首的科学界提倡改变目前抗体供应混乱状况的时代潮流。