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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:220.2Da
CASRegistry#:129-56-6
Formula:C14H8N2O
Description:
Novel,potentandselectiveJNK-1,-2,and-3inhibitor(Ki=0.19µM).SP600125isanATP-competitivereversIBLeinhibitorwith>20-foldselectivityvs.arangeofkinasesandenzymestested.Incells,SP600125causedadose-dependentinhibitionofthephosphorylationofc-Jun,theexpressionofinflammatorygenesIL-2,COX-2,TNF-α,IFN-γ,andblockedtheactivationanddifferentiationofprimaryhumanCD4cellcultures.
Synonym(s):
Anthra(1,9-cd)pyrazol-6(2H)-one,1,9-Pyrazoloanthrone,Anthrapyrazolone,JNKInhibitorII
Purity:
≥99%
Solubility:
PrepareinitialstocksolutionsinDMSO(solubleat65mg/ml)forinvitrouse;solubilityinethanolorwaterislow.
Format:
Darkyellowsolid
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Bennett,B.L.,etal.Proc.Natl.Acad.Sci.USA98:13681-13686(2001).
2.Han,Z.,etal.J.Clin.Invest.108:73-81(2001).
2.Han,Z.,etal.J.Clin.Invest.108:73-81(2001).
ScientificCategory:
PDE
ProductType:
Inhibitor
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