品牌分类
品牌咨询
- CD4 Monoclonal Antibody (RM45), PE, eBioscience
- bpsbioscience常备现货
- 求教:BPS Bioscience官网 BPS Bioscience经销商/代理商,是假货吗?
- BPS bioscience代理_上海elisa生物技术有限公司
- GABAA Receptor β2 Subunit Polyclonal Antibody
- bpsbioscience抗体产品手机版
- 【Bpsbioscience代理】_上海酶联生物
- Antibodies, Proteins, Kits and Reagents for Life Science ...
- BRD4 (BD1) Inhibitor Screening Assay Kit性能参数,报价/价格,图片...
- BPS BioscienceELISA 试剂盒
- mysql源码安装_zengzehui的专栏
- BPS bioscience_BPS bioscience
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:574.7Da
CASRegistry#:819812-04-9
Formula:C30H42N2O9
Target:HSP90
Background:
Heatshockprotein90(Hsp90)isapromisingtargetforanti-tumortherapy.KW-2478enhancedbortezomib-inducedcellgrowthinhibition,andexhibitedenhancedanti-tumoractivityagainsthumanmyeloma.
Description:
KW-2478isanovelandpotentnonansamycininhibitorofheatshockprotein90(IC50=3.8nM)designedtoovercomethelimitations,includinglowwatersolubilityandhepatotoxicity,of17-allylamino-17-demethoxygeldanamycin(17-AAG).KW-2478exertsastrongantitumoractivityagainstmultiplemyeloma(MM)cellswithvariouschromosormaltranslocations.KW-2478inhibitscellgrowthandapoptosisassociatedwithHsp90clientproteindegradation.RecentstudyresultshaverevealedthatKW-2478isabletodepleteHsp90clientCdk9andthephosphorylated4E-BP1,atranscriptionalkinaseandatranscriptioninhibitorrespectively,leADIngtoreducedexpressionofFGFR3,c-MafandcyclinD1.
Synonym(s):
KW2478;KW2478
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.NakashimaT,etal.ClinCancerRes.2010;16(10):2792-802.
2.Ishii,T.,etal.BloodCancerJ.2012Apr;2(4):e68.
2.Ishii,T.,etal.BloodCancerJ.2012Apr;2(4):e68.
ScientificCategory:
HSPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.


