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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:421.4Da
CASRegistry#:459868-92-9
Formula:C19H18FN3O•H3PO4
Target:PARP1
Background:
Rucaparib,alsonamedasAG-014699orPF-01367338,isapoly(ADPribose)polymerase(PARP)inhibitor.PARPisaDNAdamage-activatednuclearenzymethathasakeysignalingroleinthebaseexcisionrepairpathway.So,rucaparibhasbeenalsofoundtobemosteffectiveincellsdeficientinDNArepair,wherethecellsdeficientarecausedbyexposuretogenotoxicagents,suchasirrADIationproducesDNAdamageanditstoxicityisaugmentedwhentheDNArepairisimpaired.IncreasedradiosensitivityinpresenceofrucaparibwasassociatedwithpersistentDNAbreaksasdeterminedbygamma-H2AXandp53BP1foci.Rucaparibradiosensitizesprostatecancercells,mosteffectivelythosethatarePTEN-deficientandareexpressingETSgenefusionproteins,whichinhibitsNHEJDNArepair.
Description:
Rucaparib,alsoknownasAG-014699orPF-01367338,isaninhibitorofPARP1withKiof1.4nM.
Synonym(s):
Rucaparibphosphate;AG-14699;AG014699;PF-01367338;8-fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-onephosphate
Purity:
≥98%byHPLC
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Chatterjee,P.,etal.CancerResearch.2012.72:B27.
ScientificCategory:
PARPInhibitor
ProductType:
Inhibitor
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