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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:420.4Da
CASRegistry#:317-34-0
Formula:C16H24N10O4
Target:PDE
Background:
Aminophyllineisabronchodilatorthatisusedtogetherwithothermedicinestotreattheacutesymptomsofasthma,bronchitis,emphysema,andotherlungdiseases.AminophyllineisalsoacompetitiveadenosinereceptorantagoNISTanditisthoughttohavepotentialtherapeuticvalueforcardiacischemia.
Description:
Aminophyllineisanon-selectivephosphodiesterase(PDE)inhibitorwithanIC50of0.12mM.InhibitionofPDEpreventsthebreakdownofsecondarymessengermoleculescAMPandcGMP,whichplayavitalroleinsignaltransduction.
Synonym(s):
theophyllineethylenediamine;bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione);ethane-1,2-diamine
Solubility:
Solubleinwater(3.7mg/ml).Solutionsshouldbefreshlyprepared.Notsolubleinalcohols.
Format:
whitetooff-whitepowder
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Crisanti,etal.,Am.J.Physiol.277,R829-R835,(1999).
2.Chanda,etal.,Pol.J.Pharmacol.50,80-82,(1998).
3.Thakker,etal.AnalyticalProfilesofDrugSubstances2nded.,(1982)2,1-44.
2.Chanda,etal.,Pol.J.Pharmacol.50,80-82,(1998).
3.Thakker,etal.AnalyticalProfilesofDrugSubstances2nded.,(1982)2,1-44.
ScientificCategory:
PDEInhibitor
ProductType:
Inhibitor
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