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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:485.9Da
CASRegistry#:439081-18-2
Formula:C24H25ClFN5O3
Description:
Afatinib,alsoknownasBIW-2992,isanirreversIBLedualinhibitorofepidermalgrowthfactorreceptor1(EGFR)and2(HER2)tyrosinekinases.AfatinibsuppressesEGF-inducedEGFRphosphorylationandcellularproliferationinvariouscelllines,includingEGFR-overexpressingandHER2-expressingcelllinesA431,NIH-3T3-HER2,NCI-N87andBT-474.
Synonym(s):
BIW-2992
Purity:
≥95%byHPLC.
Solubility:
SolubleinDMSOat200mg/ml;solubleinethanolat25mg/ml;verypoorlysolubleinwater;maximumsolubilityinplainwaterisestimatedtobeabout50-100µM;buffers,serum,orotheradditivesmayincreaseordecreasetheaqueoussolubility.
Format:
Whitecrystallinepowder.
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Eskens,F.A.,etal.Br.J.Cancer98:80-85(2008).
ScientificCategory:
Kinase
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.


