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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:244.3Da
CASRegistry#:912444-00-9
Formula:C13H16N4O
Description:
ABT-888(Veliparib)isapotentinhibitorofbothPARP-1andPARP-2.IntheMX-1breastxenograftmodel(BRCA1deletionandBRCA2mutation),ABT-888potentiatedcisplatin,carboplatin,andcyclophosphamide,causingregressionofestablishedtumors,whereaswithcomparabledosesofcytotoxicagentsalone,onlymodesttumorinhibitionwasexhibited.
Synonym(s):
Veliparib
Purity:
≥99%byHPLC
BIOLOGicalActivity:
ABT-888(Veliparib)isapotentinhibitorofbothPARP-1andPARP-2by[3H]NAD+withKiof5.2nmol/Land2.9nmol/L,respectively.ABT-888inhibitedPARP-1withIC50of4.4nMusingBPSBiosciencePARP1ChemiluminescentAssayKit(Cat.#80551).
Solubility:
SolubleinDMSO.
Format:
Whitetobeigepowder.
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Donawho,C.K.,etal.,ClinicalCancerResearchMay200713;2728.
2.Sanchez,E.V.,etal.,Meeting:2009ASCOAnnualMeeting.Citation:JClincalOncol.27:15s,2009(suppl;abstr11028).
3.Liu,SK.,etal.,RADIotherOncol.2008Aug;88(2):258-68.
2.Sanchez,E.V.,etal.,Meeting:2009ASCOAnnualMeeting.Citation:JClincalOncol.27:15s,2009(suppl;abstr11028).
3.Liu,SK.,etal.,RADIotherOncol.2008Aug;88(2):258-68.
ScientificCategory:
PARP
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.


