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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:390.2Da
CASRegistry#:1219807-87-0
Formula:C14H19IN2O3
Description:
4-iodo-SAHAisahydrophobicderivativeofSAHA,aclassIandclassIIhistonedeacetylase(HDAC)inhibitor.SimilartoSAHA,itdemonstrates>60%inhibitionofHDAC1andHDAC6activityinadeacetylaseactivityassayat1µM.
Purity:
≥98%byHPLC
BIOLOGicalActivity:
4-iodo-SAHAinhibitsSKBR3breast-derivedandHT29colon-derivedcelllineproliferationwithEC50valuescomparabletothatofSAHA(1.1µMand0.95µMversus2.1µMand2µM,respectively).Ithas10timestheinhibitionstrengthofU937leukemiacellproliferationincomparisontoSAHA(0.12µMversus1.2µM,respectively).
Solubility:
Solubilityinethanolis0.2mg/mland30mg/mlinDMSOandDMF.First,dissolveinDMSOthendilutewiththeaqueousbufferofchoice.
Format:
Acrystallinesolid
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Salmi-Smail,C.,etal.,J.Med.Chem.2010;53:3038–3047.
ScientificCategory:
HDAC
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.


