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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:312.4Da
CASRegistry#:935881-37-1
Formula:C8H20N2O3
Description:
(S)-HDAC-42isastronginhibitorofHDACs.ItdecreasestheviABIlityofprostatecancercelllinesbyincreasingtheexpressionofp21andtheacetylationofhistoneH3whiledecreasingAktphosphorylationandBcl-XLexpression.TheinhibitorsuppressesthegrowthofPC-3tumorxenografts,reducinglevelsofphospho-AktandBcl-XLproteinintumors.
Purity:
≥95%byHPLC
BIOLOGicalActivity:
(S)-HDAC-42inhibitsHDACswithIC50=16nMinvitro.
Solubility:
Solubleinethanol,DMSOandDMF,whichshouldbepurgedwithaninertgas.Solubilityinthesesolventsis~20mg/ml.Fororganicsolvent-freeaqueoussolutions,preparebydirectlydissolvingthecrystallinecompoundinaqueousbuffers.
Format:
Acrystallinesolid
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Lu,Q.,etal.,J.Med.Chem.2005;48:5530-5535
2.Kulp,S.K.,etal.,Clin.CancerRes.2006;12(17):5119-5206.
2.Kulp,S.K.,etal.,Clin.CancerRes.2006;12(17):5119-5206.
ScientificCategory:
HDAC
ProductType:
Inhibitor
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