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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:302.4Da
CASRegistry#:362-07-2
Formula:C19H26O3
Background:
2-MethoxyestrADIoliscurrentlyinclinicaltrialsasatherapeuticagainstbreastandovariancancer.Preclinicalmodelsalsosuggestthat2ME2couldalsobeeffectiveagainstinflammatorydiseasessuchasrheumatoidarthritis.Severalstudieshavebeenconductedshowing2ME2isamicrotubule-inhibitorandeffectiveagainstprostatecancerinrodents
Description:
2-Methoxyestradiol(2-MeOE2),anendogenousmetaboliteof17β-estradiol(E2),isaninhibitorofmicrotubuleassemblythatinhibitsthepolymerizationoftubulinandinterfereswithmitoticspindledynamicsleadingtotheblockageofmitosisofhumancancercellswhichlackestrogenreceptorsinmetaphase.2-MeOE2isalsoaninhibitoroftumorgrowthandangiogenesis.Studyresultshaveshownthat2-MeOE2inducesmammaliancelltransformationandgenotoxicityinSyrianhamsterembryo(SHE)fibroblaststhroughconcentration-dependentinhibitionofcellgrowth.Moreover,2-MeOE2hasdemonstratedanti-proliferativeactivityagainstestrogen-responsivebreastcancercelllineMCF-7andsubsequentinhibitionofthegrowthoftumorssubcutaneouslyinoculatedinmice.
Synonym(s):
2-Methoxyestradiol;2-MeOE2;2-methoxyEstradiol
Purity:
98%puritybyHPLC
Solubility:
SolubleinDMSO~20mg/ml
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Tsutsui,T.,etal.Carcinogensis2000;21(4):735-740.
2.Attalla,H.,etal.Biochem.Biophys.Res.Commun.1996;228:467-473.
2.Attalla,H.,etal.Biochem.Biophys.Res.Commun.1996;228:467-473.
ScientificCategory:
ApoptosisInducer
ProductType:
Activator/Inducer
Datashownislot-specific.Contactusforspecificinformationonotherlots.


