DescriptionLiposomal formulations

Clodronate liposomes:

Artificial spheres consisting of concentric phospholipid bilayers encapsulating an aqueous PBS (phosphate buffered saline) solution containing clodronate. Liposomes are particles, sized at a max. of 3 micron. They form a suspension in PBS and will tend to precipitate upon storage, forming a pellet on the bottom of the tube or flask. The suspension should be shaken before administration to laboratory animals in order to recover the homogeneous suspension. The concentration of clodronate in the suspension is ca. 5 mg/ml.

Control liposomes (PBS):

Control liposomes do not contain clodronate. Containing PBS only, they can be used for control experiments, in order to find out whether the effects observed after injection of clodronate liposomes are due to macrophage depletion exclusively.

去除巨噬细胞（depletion of macrophages）。去除巨噬细胞是研究巨噬细胞功能的重要方法，该产品利用巨噬细胞的内吞机制，将膜不通透性的氯磷酸（clodronate）带入细胞内，氯磷酸被释放，当达到一定的浓度时可引发巨噬细胞的凋亡，从而达到去除巨噬细胞的目的。