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Info

MVL5

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

New Multivalent Cationic Lipid for siRNA Delivery

• Improved total gene silencing• Lower non-specific gene silencing• Lower toxicity

These attributes establish the multivalent MVL5 as a superior transfection vector for siRNAs, and have implications for the optimal use of cationic lipids in therapeutic applications.

Now available as a pre-mixed kit, MVL5 and GMO ready to use.Avanti Number 640009

Data

Hygroscopic

No

Light Sensitive

No

Molecular Formula

C₅₉H₁₁₆Cl₅N₇O₄

Percent Composition

C 60.83%, H 10.04%, Cl 15.22%, N 8.42%, O 5.49%

Purity

>99%

Stability

1 Year

Storage Temperature

-20°C

CAS Number

464926-03-2 CAS Registry Number is a Registered Trademark of the American Chemical Society

FormulaWeight

1164.862

Exact Mass

1161.754

Synonyms

N1,N1,N4-tris(3-ammoniopropyl)-5-((2-(3,4-bis((Z)-octadec-9-en-1-yloxy)benzamido)ethyl)amino)-5-oxopentane-1,4-diaminium chloride

Downloads

ChemDraw File
3D Structure
Structure
Safety Data Sheet

References

Ravi V, Madhankumar AB, Abraham T, Slagle-Webb B, Connor JR. Liposomal delivery of ferritin heavy chain 1 (FTH1) siRNA in patient xenograft derived glioblastoma initiating cells suggests different sensitivities to radiation and distinct survival mechanisms. PLoS One. 2019 Sep 6;14(9):e0221952. doi: 10.1371/journal.pone.0221952. eCollection 2019.

PubMed ID: 31491006

Guevara ML, Jilesen Z, Stojdl D, Persano S. Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration. ACS Omega. 2019 Aug 7;4(8):13015-13026. doi: 10.1021/acsomega.9b00489. eCollection 2019 Aug 20.

PubMed ID: 31460428

Chan CL, Ewert KK, Majzoub RN, Hwu YK, Liang KS, Leal C, Safinya CR. Optimizing cationic and neutral lipids for efficient gene delivery at high serum content. J Gene Med. 2014 Mar-Apr;16(3-4):84-96. doi: 10.1002/jgm.2762.

PubMed ID: 24753287

Leal C, Ewert KK, Shirazi RS, Bouxsein NF, Safinya CR. Nanogyroids incorporating multivalent lipids: enhanced membrane charge density and pore forming ability for gene silencing. Langmuir. 2011 Jun 21;27(12):7691-7. doi: 10.1021/la200679x. Epub 2011 May 25.

PubMed ID: 21612245

Bouxsein NF, McAllister CS, Ewert KK, Samuel CE, Safinya CR. Structure and gene silencing activities of monovalent and pentavalent cationic lipid vectors complexed with siRNA. Biochemistry. 2007 Apr 24;46(16):4785-92. Epub 2007 Mar 29.

PubMed ID: 17391006

Ewert K, Ahmad A, Evans HM, Schmidt HW, Safinya CR. Efficient synthesis and cell-transfection properties of a new multivalent cationic lipid for nonviral gene delivery. J Med Chem. 2002 Nov 7;45(23):5023-9.

PubMed ID: 12408712

avanti极性脂质/N1-[2-（（1S）-1-[（3-氨基丙基）氨基]-4-[二（3-氨基丙基）氨基]丁基甲酰胺）乙基]-3,4-二[油酰氧基]-苯甲酰胺/1 x 1mg/890000P-1mg

890000 | MVL5

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide

MVL5

N1-[2-((1S)-1-[(3-aminopropyl)amino]-4-[di(3-amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide