- 细胞因子
- Dihydropyrimidinase and Proteins
- Regulatory proteins
- 授予称号
- Peptide Substrates
- Isoform Specific Antibodies
- Deacetylase & Demethylase Proteins
- Acetyl & Methyltransferase Proteins
- siRNA Controls
- Cell Stress and Chaperone Proteins
- 激酶
- 双加氧酶与蛋白质
- Transcription Proteins
- Carbohydrate Kinases
- 表观遗传酶抑制剂
- Growth Factors
- 脂类激酶
- Phospholipase C and Proteins
- Mutant Kinases
- Oligo Substrates
- Fluorescent and Color Proteins
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Overview:
EZH2 (enhancer of zeste homolog 2) belongs to the polycomb group (PcG) protein and acts as the catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of target genes. EZH2 expression is associated with proliferating tissues and shares an overlapping set of target genes with EZH1. Compared to PRC2-EZH1, PRC2-EZH2 exhibits higher levels of histone methyltransferase (HKMT) activity.
Gene Aliases:
ENX-1, EZH1, MGC9169
Genbank Number:
BC010858
References:
1. Margueron R, et al: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 32(4):503-18, 2008.2. Shen X, et al: EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 32(4):491-502, 2008
