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Overview:
EZH2 (enhancer of zeste homolog 2) belongs to the polycomb group (PcG) protein and acts as the catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of target genes. EZH2 expression is associated with proliferating tissues and shares an overlapping set of target genes with EZH1. Compared to PRC2-EZH1, PRC2-EZH2 exhibits higher levels of histone methyltransferase (HKMT) activity.
Gene Aliases:
ENX-1, EZH1, MGC9169
Genbank Number:
BC010858
References:
1. Margueron R, et al: Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 32(4):503-18, 2008.2. Shen X, et al: EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 32(4):491-502, 2008
