- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
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- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
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- E3
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- SignalChem|生产厂家|价格信息
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Overview:
Thetranslationalrepressorprotein4EBP1interactsdirectlywitheukaryotictranslationinitiationfactor4E(EIF4E).Thisinteractioninhibitstheformationofthemulti-subunitcomplexthatrecruits40Sribosomalsubunitstothe5"endofmRNAsthuspreventingcap-dependenttranslation.Hyperphosphorylationof4EBP1disruptsitsbindingwithEIF4E(1).TreatingADIposecellswithinsulinleadstoincreased4EBP1phosphorylation(1).4EBP1isexpressedinmosttissues,withhighlevelsdetectedinadiposetissue,pancreasandskeletalmuscle(2).4EBP1isphosphorylatedatseveralresiduesincludingThr45inresponsetothephorbolesterTPA.
References:
1.Pause,A.etal:Insulin-dependentstimulationofproteinsynthesisbyphosphorylationofaregulatorof5-prime-capfunction.Nature371:762-767,1994.,br>2.Tsukiyama-Kohara,K.etal:Tissuedistribution,genomicstructure,andchromosomemappingofmouseandhumaneukaryoticinitiationfactor4E-bindingproteins1and2.Genomics38:353-363,1996.
