IBL/抗Dock6兔IgG亲和纯化/JP28111/

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货号:JP28111
浏览量:127
品牌:IBL
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全国联保
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商品描述
Quantity/Tests100µg
Species/AntigenSyntheticpeptide
HostRabbit
Subclass/CloneN/A
TypeN/A
PurificationPurifiedwithantigenpeptide
LabelN/A
RegulatoryStatus:Forresearchuseonly
Detailsfor: Anti-Dock6RabbitIgGAffinityPurify
SmallGTPaseofRhofamilyisoneofsignalingfactorswhichcontrolalterationofcellularmorphology,celldivisionanddifferentiation,andplaysanimportantroleinregulationofgenerationandorganogenesisatanindividuallevel.Itsfunctionsarestrictlyregulatedanditsdysfunctioncausesmanydiseasessuchasimmunologicaldiseaseorneurodegenerativedisease.
Dedicatorofcytokinesis(Dock)6isaRhofamilysmallGTPaseactivatingfactor(orexchangefactor)activatingRac1andCdc42specificallyoftheRhofamilysmallGTPase,andiswidelyexpressedmolecule.ItisnotedthatDock6isanimportantfactorforproliferationanddifferentiationofneurocytessinceitismoreexpressedespeciallyinbrainandsensorynervetissues.Additionally,itisknownasaresponsIBLegeneforAdams-Oliversyndrome,inwhichdisordersofdeliveryandsexualdifferentiationareobserved,andwhichisassociatedwithmetabolicdisorderandintelligencedisorder.IthasbeenreportedthatmutationsinDock6causedeclineofitsfunctionandleadtoabnormalCytoskeletonorganization.
Thereareproteins,calledDock7andDock8,verysimilartoDock6inhumanbuttherearestillmanyunclearpointsabouttheirregulationsystems.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立,旨在开发测量,分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中,这是首席执行官兼创始人亨氏·阿普兰纳普(Heinz Abplanalp)的家庭住宅。