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商品描述
| Quantity/Tests | 100µg |
| Species/Antigen | HumanIgA1hingeregionpeptidewithGalNAc |
| Host | Rat |
| Subclass/Clone | IgG |
| Type | Polyclonal |
| Purification | ProteinA |
| Label | No |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Anti-humanGd-IgA1(KM55)RatIgG
iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立，旨在开发测量，分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中，这是首席执行官兼创始人亨氏·阿普兰纳普（Heinz Abplanalp）的家庭住宅。 "Originalarticle#10777
Galactose-deficientIgA1(Gd-IgA1)attractsalotofattentionsasacriticaleffectormoleculeinthepathogenesisandprogressionofIgAnephropathy(IgAN)inrecentstudies.IthasbeensuggestedthatseveralO-linkglycansmodifiedregionsexistintheheavychainhingeregionofhumanIgA1moleculeandGd-IgA1circulatesinthebloodstreamofpatientswiththepathologicalconditionofIgAN.ThedepositionofGd-IgA1inglomeruliisconsideredtobeinvolvedinIgAN(Multi-hitHypothesisofGd-IgA1).Themeasuringsystemusingsnail(Helixaspersa;HAA)lectinthatisextractedfromsnailandGd-IgA1ELISA(Code:27600Gd-IgA1(Galactose-deficientIgA1)AssayKitusingthisantibody(KM55)havebeenusedinnumerousstudiesandithasbeensuggestedthatserumlevelsofGd-IgA1inpatientswithIgANissignificantlyelevatedcomparedtothelevelsofhealthysubjectsorpatientswithrenaldiseaseotherthanIgANinsuchstudies.Inaddition,thisantibody(KM55)candetectGd-IgA1intissuebyIHCtechniquedifferentlyfromthefeatureofHAAlectinandithasbeenrevealedthatGd-IgA1specicillayexistsinglomeruliofthepatientsofIgANfromthestudiesusingthisantibody.IthasbeenexpectedthatclinicalsignificanceofGd-IgA1wilberevealedbyfurtherstudiesusingthisantibody."
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Galactose-deficientIgA1(Gd-IgA1)attractsalotofattentionsasacriticaleffectormoleculeinthepathogenesisandprogressionofIgAnephropathy(IgAN)inrecentstudies.IthasbeensuggestedthatseveralO-linkglycansmodifiedregionsexistintheheavychainhingeregionofhumanIgA1moleculeandGd-IgA1circulatesinthebloodstreamofpatientswiththepathologicalconditionofIgAN.ThedepositionofGd-IgA1inglomeruliisconsideredtobeinvolvedinIgAN(Multi-hitHypothesisofGd-IgA1).Themeasuringsystemusingsnail(Helixaspersa;HAA)lectinthatisextractedfromsnailandGd-IgA1ELISA(Code:27600Gd-IgA1(Galactose-deficientIgA1)AssayKitusingthisantibody(KM55)havebeenusedinnumerousstudiesandithasbeensuggestedthatserumlevelsofGd-IgA1inpatientswithIgANissignificantlyelevatedcomparedtothelevelsofhealthysubjectsorpatientswithrenaldiseaseotherthanIgANinsuchstudies.Inaddition,thisantibody(KM55)candetectGd-IgA1intissuebyIHCtechniquedifferentlyfromthefeatureofHAAlectinandithasbeenrevealedthatGd-IgA1specicillayexistsinglomeruliofthepatientsofIgANfromthestudiesusingthisantibody.IthasbeenexpectedthatclinicalsignificanceofGd-IgA1wilberevealedbyfurtherstudiesusingthisantibody."
