IBL/抗人CD109(11H3)小鼠IgG/JP10381/

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货号:JP10381
浏览量:127
品牌:IBL
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商品描述
Quantity/Tests100µg
Species/AntigenRecombinantproteinofC-terminalportionofhumanCD109
HostMouse
Subclass/CloneIgG1/11H3
TypeMonoclonal
PurificationProteinA
LabelNo
RegulatoryStatus:Forresearchuseonly
Detailsfor: Anti-humanCD109(11H3)MouseIgG
CD109isaglycosyl-phosphatidyl-inositol(GPI)-anchoredglycoproteinabout180-190kDasize.ItisshownthatCD109isexpressedinvascularendothelialcells,someepithelialcells,activatedT-cellsandplatelets,andsubsetofCD34+megakaryocyticleukemiacells.TheCD109moleculesarestronglyexpressedinKG1acells,whileCD34+CD109+cellsinfetalbonemarrowincludealmostallmyelocytic,erythroblasticandmegakaryocyticprecursorcells.Forthisreason,CD109isconsideredtobeaMarkerofmegakaryocytichematopoiesisinearlystage.AndCD109isconsidereddifferentfromexistingactivationmarkersofleukocytesandplatelets,becauseofitsstructureandSEROlogicalfeatures.ByreportsofTakahashietal.,CD109issignificantlyoverexpressedinsquamouscellcarcinomassuchaslungcarcinoma,esophagealcarcinomaanduterinecervicalcarcinoma.Thus,itisattractingattentionforstudyingsquamouscellcarcinomas.Additionally,arecentstudysuggeststhatCD109isinvolvedintheregulationoftransforminggrowthfactor(TGF)-βsignalinginsomecancercellsandkeratinocytes.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立,旨在开发测量,分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中,这是首席执行官兼创始人亨氏·阿普兰纳普(Heinz Abplanalp)的家庭住宅。