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蚂蚁淘在线 / 品牌中心 / IBL / IBL/sP-Selectin (monkey) ELISA/BE45741/

IBL/sP-Selectin (monkey) ELISA/BE45741/

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面议
货号：BE45741
浏览量：127
品牌：IBL
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Kitsize12x8
MethodELISA
Incubationtime1x2h,1x10min
Standardrange2.3-150U/mL
Specimen/Volumes10µLserum,plasma,cellculturesupernatantetal.
Substrate/isotopeTMB450nm
RegulatoryStatus:Forresearchuseonly
Detailsfor: sP-Selectin(monkey)ELISA
P-selectinbelongstotheselectinfamilyofadhesionmolecules.P-selectinactsasareceptorthatsupportsbindingofleukocytestoactivatedplateletsandendothelium.P-selectinisa140kDaproteinthatishighlyglycosylated.TheCDNAderivedaminoacidsequencepredictsamoleculewithaseriesofcysteine-richdomains.P-selectinislocatedinmembranesofagranulesinunstimulatedplateletsandredistributedtothecellsurfaceuponplateletactivation.P-selectinisalsopresentinendothelialcellsinmembranesofWeibel-Paladebodiesandmegakaryocytes.ThephysiologicroleofP-selectinmightbethemediationofinitialleukocyteadhesiontoactivatedendotheliumduringacuteinflammation.ItmayworkinconcertwithE-selectintodirectearly,regionallyspecificadherenceofneutrophilsandmonocytesatsitesofacuteinflammation.AsolubleformofP-selectinfoundinserumandplasmahasbeendescribedwhichmightrepresentaproteolyticfragmentormorelikelyasolublesplicevariantlackingthetransmembranedomain.
ExcessiveaccumulationofneutrophilsontheendothelialsurfaceaccompaniedbyhighexposureofP-selectinhasbeenimplicatedinanumberofinflammatorydisorders,includingadultrespiratorydistresssyndrome,acutelunginjury,ischemia-reperfusioninjury,Gram-negativesepticshock,thromboticdiseasesandrheumatoidarthritis.MalignantcellswereshowntoexpressreceptorsforP-selectinsuggestinganimportantroleforP-selectinintumorformationandmetastasis.

Synonyms:Granulemembraneprotein140,PADGEM,CD62P
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立，旨在开发测量，分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中，这是首席执行官兼创始人亨氏·阿普兰纳普（Heinz Abplanalp）的家庭住宅。