IBL/sE选择素(猴)ELISA/BE45721/

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面议
货号:BE45721
浏览量:127
品牌:IBL
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Kitsize12x8
MethodELISA
Incubationtime1x2h,1x10min
Standardrange1.9-60U/mL
Specimen/Volumes20µLserum,plasma,cellculturesupernatantetal.
Substrate/isotopeTMB450nm
RegulatoryStatus:Forresearchuseonly
Detailsfor: sE-Selectin(monkey)ELISA
EndothelialLeukocyteAdhesionMolecule-1belongstotheselectinfamilyofadhesionmolecules.TogetherwithL-selectinandP-selectin,E-selectinmediatestheinitialinteractionsofleukocytesandplateletswithendothelialcells.Molecularstructure:Theextracellularpartofallselectinsconsistsofanaminoterminalc-typelectindomainwhichspecificallybindstocarbohydrateligands.ThisisfollowedbyanEGF-likedomain,and,inthecaseofE-selectin,by6shortconsensusrepeats.Thetransmembraneportionofthemoleculeisfollowedbyashortcytoplasmictail.Selectinsguidenon-activatedpolymorphonuclearcellstotheareasofinflammationincreatingfirst,loosecontactswiththeendotheliallayer.TogetherwithP-selectin,E-selectinisexpressedoncytokine-activatedendothelialcells,andcontributestotheadhesionofstillrestingleukocytestotheendothelium.Thisinitialbindingeventisanessentialprerequisitefortheactivationoftheimmunecellsviadifferentinflammatorymediators.IncontrasttoP-selectin,E-selectinismaximallyexpressed2-4hoursaftercellactivation.Withinthenext24-48hoursE-selectinisagaineliminatedfromthecytoplasmicmembranebysheddingintothecirculation.

Synonyms:ELAM1,endothelialadhesionmolecule1,CD62E
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立,旨在开发测量,分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中,这是首席执行官兼创始人亨氏·阿普兰纳普(Heinz Abplanalp)的家庭住宅。