IBL/TNF-α(大鼠)ELISA/BE45471/

价格
面议
货号:BE45471
浏览量:127
品牌:IBL
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商品描述
Kitsize12x8
MethodELISA
Incubationtime1x2h,1x1h,1x10min
Standardrange39.1-2500pg/mL
Specimen/Volumes50µLserum,cellculturesupernatant
Substrate/isotopeTMB450nm
RegulatoryStatus:Forresearchuseonly
Detailsfor: TNF-alpha(rat)ELISA
TumorNecrosisFactoralpha(TNF-alpha),alsoknownascachectin,isapolypeptidecytokineproducedbymonocytesandmacrophages.Itfunctionsasamultipotentmodulatorofimmuneresponseandfurtheractsasapotentpyrogen.TNF-alphacirculatesthroughoutthebodyrespondingtostimuli(infectiousagentsortissueinjury),activatingneutrophils,alteringthepropertiesofvascularendothelialcells,regulatingmetabolicactivitiesofothertissues,aswellasexhibitingtumoricidalactivitybyinducinglocalizedbloodclotting.TNF-alphaalsoinhibitslipoproteinlipaseactivityresultingincachexia,aphysicalwastingcondition.Duetoitsvariedactionsthroughouttheimmunesystem,TNF-alphamayplayaroleinthepathogenesisofmanydiseasestates.TNF-alphaproductionismediatedbytheactionoflymphokinesandendotoxinsonthemacrophage.PurifiedmonocytesproduceTNF-alphawithinfourhoursofstimulationbyrecombinantIL-2andthereissomeinvitroevidencetosuggestthatTNF-alphaisexpressedathighlevelsandwithprolongedkineticsinTcellsstimulatedbybothCD2andCD28.SecretionofTNF-alphaisenhancedbygammainterferon.TNFtheninducesorenhancesthespecificproductionofClassIMHCantigen,GM-CSF,andIL-1.Recentevidencehassuggestedanintracellularroleforthispeptide.

Synonyms:Cachectin,Tumornecrosisfactoralpha,DIF
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立,旨在开发测量,分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中,这是首席执行官兼创始人亨氏·阿普兰纳普(Heinz Abplanalp)的家庭住宅。