IBL/IL-17AF/IL-17AF(小鼠)ELISA/BE45071/

价格
面议
货号:BE45071
浏览量:127
品牌:IBL
服务
全国联保
正品保证
正规发票
签订合同
商品描述
Kitsize12x8
MethodELISA
Incubationtime1x2h,1x1h,1x30min
Standardrange3.9-250pg/mL
Specimen/Volumes50µLserum,plasma,cellculturesupernatantetal.
Substrate/isotopeTMB450nm
RegulatoryStatus:Forresearchuseonly
Detailsfor: Interleukin-17AF/IL-17AF(mouse)ELISA
IL-17AandIL-17FaremembersoftheIL-17familyandsignatureTh17cytokines.OfthesixIL-17familymembers,IL-17FandIL-17Asharethestrongesthomology(50%aminoacididentity)andthetwogenesarelocatedinthesamechromosomalregion.AlthoughbothIL-17AandIL-17Fwereoriginallyfoundtobeproducedasdisulfide-linkedhomodimers,recentstudieshaveconfirmedtheproductionofIL-17AFheterodimersininvitro-differentiatedandpolarizedTh17cells.ActivatedhumanCD4+TcellsinculturewerefoundtosecretetheIL-17Fhomodimerat10-foldhigherlevelsthantheIL-17Ahomodimer,suggestingthatthemajorityoftheIL-17AproteinexpressedexistsintheformoftheIL-17AFheterodimer.StudiesofTh17-polarizedmousesplenocytesalsoindicatethatthemajorityofIL-17producediscomplexedastheIL-17AFheterodimer.IL-17FandIL-17Ahavebeenobservedintissuesamplesfromvariousautoimmunediseases,suchasrheumatoidarthritis,multiplesclerosis,psoriasis,inflammatoryboweldisease,andasthma.

Synonyms:Interleukin17AF,IL-17A/Fheterodimer
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立,旨在开发测量,分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中,这是首席执行官兼创始人亨氏·阿普兰纳普(Heinz Abplanalp)的家庭住宅。