IBL/抗干扰素-α(抗干扰素-α)ELISA/BE51051/

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¥10020.00
货号:BE51051
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品牌:IBL
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Kitsize12x8
MethodELISA
Incubationtime1x2h,1x1h,1x10min
Standardrange3.1-200ng/mL
Specimen/Volumes20µLserum,plasma,cellculturesupernatantetal.
Substrate/isotopeTMB450nm
RegulatoryStatus:Forresearchuseonly
Detailsfor: Anti-Interferon-alpha(Anti-IFN-alpha)ELISA
Studiesonantigenicityledtotheconceptthatmoleculesliketheinterferonswerenotimmunogenicinhomologoussystemsbecauseantibodiesarenotnormallyproducedagainst"self"antigens.However,naturallyoccuringortherapeuticallyinducedantibodiestocytokinessuchasinterferons,tumornecrosisfactors(TNF),interleukins(IL)andvariousgrowthfactorswerefound,whicharegenerallythoughttoinhibitcytokinefunctions,andtheappearanceofsuchantibodiesshouldthereforeresultinvariousdegreesofcytokinedeficiency.Itisacommonconceptthatthedevelopmentofantibodiesagainstanyautoantigenordrugisalwaysundesirable.SuchantibodiesarecrucialforthepathologyofautoimmunediseasesandinhibitthepharmacologicaleffectsofdrugsincludingexogenouslyadmiNISTeredcytokines.

Naturalantibodies:AntibodiestoIFN-alphahavebeenreportedinpatientswithvariousautoimmunedisorders.AntibodiestoIFN-alphaweredetectedintheserumofpatientswithsystemiclupuserythematosus.TherearereportsofnaturalantibodiestoIFN-alphainpatientssufferingfromherpeszosterinfections,andvaricellazosterdisease.SpontaneousantibodiestoIFN-alphawereshowntooccurinseraofvariouscancerpatients.

Therapeuticallyinducedantibodies:FormationofantibodiesagainstIFN-alphahasbeenreportedinpatientsaftertreatmentwithallavailablehumanIFNpreparationsregardlessoftheircompositionandsubtypes.MoreandmorereportsindicatethatrelapsesaftersuccessfulIFN-alphatherapycoincidetheformationofneutralizingantibodiesagainstIFN-alpha.

Leukemias/lymphomas:ClinicalresistanceandIFN-alphaantibodieshavebeenfoundinpatientswithhairycellleukemia,chronicmyeloidleukemia,chroniclymphoidleukemia,multiplemyeloma,essentialthrombocytemia,preleukemia,andKaposi"ssarcoma.

Solidtumors:TreatmentofpatientswithsolidtumorsmayalsoinduceIFN-alphaantibodyformationasshownfor:malignantmelanoma,renalcellcarcinoma,nasopharyngealcarcinoma,breastcarcinoma,variousadvancedcarcinomas,urinarybladdercarcinomaandgenitalaswellasrespiratorypapillomatosis.
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iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立,旨在开发测量,分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中,这是首席执行官兼创始人亨氏·阿普兰纳普(Heinz Abplanalp)的家庭住宅。