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蚂蚁淘在线 / 品牌中心 / IBL / IBL/膜联蛋白V-Ab ELISA/BE59331/

IBL/膜联蛋白V-Ab ELISA/BE59331/

价格
面议
货号：BE59331
浏览量：127
品牌：IBL
服务
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Kitsize12x8
MethodELISA
Incubationtime1x2h,1x10min.
Standardrange6.3-400ng/mL
Specimen/Volumes50µLserum,cellculturesupernatant
Substrate/isotopeTMB450nm
RegulatoryStatus:Forresearchuseonly
Detailsfor: AnnexinV-AbELISA
Annexinsareafamilyofcalcium-dependentphospholipid-bindingproteins.AllannexinshavebeenshowntohaveputativebindingsiteforproteinkinasesCbutonlyannexinVwouldpossessapotentialpseudo-substratesite.ThusannexinVseemstomodulatetheactivityofsomePKCsontheirsubstrates.

AnnexinVwasfoundtoplayamajorroleinmatrixvesicle-initiatedcartilagecalcificationasacollage-regulatedcalciumchannel.AnnexinVspreferentialbindingpartnerisphosphatidylserine(PS).PSispredominantlylocatedinmembraneleaflets,whichfacethecytosol.However,recentfindingsshowthateachcelltypehasthemolecularmachinerytoexposePSatitscellsurface.Thismachineryisactivatedduringtheexecutionofapoptosis.OncePSisexposedatthecellsurfaceitexhibitsprocoagulantandproinflammatoryactivities.AnnexinVwillbindtothePS-exposingapoptoticcellandcaninhibittheprocoagulantandproinflammatoryactivitiesofthedyingcell.ThesefindingstogetherwiththepresenceofAnnexinVintheextracellularspacedepictanovelpathophysiologicalsignificanceforAnnexinVinvivo.

TheoccurrenceofautoantibodiestoannexinVhasbeendescribedinseveralpathologicaldisorders.ItisconcludedthatextracellularannexinVprovidesanantigenicstimulusforautoantibodyproduction.SuchautoantibodiesmayhaveadetrimentalroleinterferingwithputativefunctionsofannexinV.
Synonyms:antiAnnexinA5,antiAnnexin5
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
iBL的Tecan由四名工程师于1980年在瑞士Hombrechtikon村成立，旨在开发测量，分析和实验室自动化设备。最初的办公室位于经过翻新的农舍中，这是首席执行官兼创始人亨氏·阿普兰纳普（Heinz Abplanalp）的家庭住宅。