ProductName	RetinoidXReceptoralpha,RXRA
Size	10,000U
Description	Nuclearreceptorsformthelargestknownfamilyoftranscriptionfactorsandhaveacrucialroleinnearlyallaspectsofvertebratedevelopmentandadultphysiologybytransducingtheeffectsofhormonesintotranscriptionalresponses(1).Thefamilyisdefinedbytwodomains:(a)thecentral,highlyconserved,DNA-bindingdomain(DBD)ofapprox.66aminoacids,and(b)theC-terminal,structurallyconserved,ligand-bindingdomain(LBD)ofapprox.250aminoacids(2,3).InadditiontobindingtoDNAandactivatingtranscriptioninresponseto9-cisretinoicacid,RXRformsheterodimerswiththereceptorsforthyroidhormone(TR),retinoicacid(RAR),vitaminD(VDR),prostanoids(PPAR),andnumerousorphanreceptors(4).RXRactsasbothactivatorandrepressoroftranscription(5).Intheabsenceofhormone,RXR(homo-orheterodimer)interactswithSMRT(silencingmediatorforretinoidandthyroidhormonereceptors)andN-CoR(nuclearreceptorcorepressor)andrepressestranscriptionthroughrecruitmentofhistonedeacetylases(6,7).Inthepresenceofhormone,RXRinteractswithanumberofactivatorsincludingtheSRC-1family(8),CBP/p300(9),pCAF(10)andtheTRAPcomplex(11)totargetchromatinacetylationactivateoftranscription(12)
Applications	reconstitutedinvitrotranscriptionassays protein-proteininteractionsassays
Source	E.coli
FusionTag	6XHis
PurificationMethod	FPLC
UnitDefinition(Activity)	1unitequalsto1nanogramofpurifiedprotein.1unitissufficientforagelmobilityshiftassayina20µlreaction;100unitsaresufficientforprotein-proteininteractionassays
Purity	~95%asdeterminedbySDS-PAGE
GeneID	6256
Accession#	NM_002957
GeneName	retinoidXreceptor,alpha
GeneSymbol	RXRA
GeneSynonyms	NR2B1
MW	53.3kDa
ProteinSequence	MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
StorageBuffer	20mMTris-HCl,pH8.0,250mMNaCl,1mMDTT,50%Glycerol
Storage	-20to-80°C.
Shipping	4°Cordryice
References	1.Mangelsdorf,D.J.,etal.,(1995)Cell83,835–839 2.Glass,C.K.(1994)Endocrinol.Rev.15,391–407 3.Moras,D.,etal.,(1998)Curr.Opin.CellBiol.10,384-391 4.KliewerS.A.,etal.,(1992)Nature355,446–449 5.GlassC.K.,etal.,(1989)Cell59,697-708 6.NagyL.,etal.,(1997)Cell89,373-380 7.Heinzel,T.,etal.,(1997)Nature387,43-48 8.Onate,S.A.,etal.,(1995)Science270,1354-1357 9.Kamei,Y.,etal.,(1996)Cell85,403-414 10.Blanco,J.C.,etal.,(1998)GenesDev.12,1638-1651 11.Fondell,J.D.,etal.,(1996)Proc.Natl.Acad.Sci.USA93,8329-8333 12.Wolffe,A.,etal.,(1997)GenesCells2,291-302

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