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蚂蚁淘在线 / 品牌中心 / Excellgen品牌新闻

Excellgen/Dr1 (NC2b 19 kDa)/RP-26/10,000 U

作者： 时间：2026-02-18 点击量：

Product Name

Dr1 (NC2b 19 kDa)

Size10,000 U
DescriptionDr1 is a general negative regulator of class II and class III gene expression (1, 2). It binds to the basic repeat domain of TBP on promoter DNA and can prevent the RNA polymerase II holoenzyme, or its TFIIB and/or TFIIA subunits, from assembling into an initiation complex (3, 4). Dr1 is phosphorylated in vivo and this modification affects its interaction with TBP (1). In addition, Dr1 interacts with the hyperphosphorylated form of Pol II and with the repression domain of the AREB6 repressor (5, 6). Dr1 forms a heterodimer complex with DRAP1 through its histone fold domain (7). More recently it was discovered that Dr1-DRAP1 is a bi-functional basal transcription factor that differentially regulates gene transcription through DPE (downstream promoter elements) or TATA box motifs (8). It can stimulate transcription in vitro from Drosophila promoters containing DPEs, whereas it represses transcription from TATA-containing promoters (8).
Applications
  • reconstituted in vitro transcription assays
  • protein-protein interactions assays
SourceE. coli
Fusion TagHis
Purification MethodFPLC
Unit Definition (Activity)

1 unit equals to 1 nanogram of purified protein. 1 unit is sufficient for a gel mobility shift assay in a 20 µl reaction; 100 units are sufficient for protein-protein interaction assays

Purity

~ 95% as determined by SDS-PAGE

Gene ID1810
Accession #NM_001938
Gene Namedown-regulator of transcription 1, TBP-binding (negative cofactor 2)
Gene SymbolDR1
Gene SynonymsNC2; NC2-BETA
MW20.6 kDa
Protein SequenceMASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNKSEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK RRKASSRLEN LGIPEEELLRQQQELFAKAR QQQAELAQQE WLQMQQAAQQ AQLAAASASA SNQAGSSQDE EDDDDI
Storage Buffer20 mM Tris-Cl (pH 8.0), 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Storage-20 to -80 °C.
Shipping4°C or dry ice
References1. Inostroza, J.A., et al., (1992) Cell 70, 477-4892. White, R.J., et al., (1994) Science 266, 448-4513. Mermelstein, F., et al., (1996) Genes Dev. 10, 1033-10484. Kim, T.K., et al., (1995) J. Biol. Chem. 270, 10976-109815. Castano, E., et al., (2000) Proc. Natl. Acad. Sci. USA 97, 7184-71896. Ikeda, K., et al., (1998) Mol. Cell. Biol. 18, 10-187. Goppelt, A., et al., (1996) EMBO J. 15, 3105-31168. Willy, P. J., et al., (2000) Science 290, 982-98589.Denko et al., (2003) J. of Bio. Chem., 278:5744-5749

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