Multichannel evaluation in Cell proliferation or Cell cytotoxicity is important. It’s vital for double-checking them and detailed cell proliferation or cytotoxic effects. Cell proliferation was evaluated by WST-8 assay and Brdu assay; Cell cytotoxicity was checked by LDH assay, WST-8 assay and trypan blue exclusion in this report. see moreUsing measurements from the LDH assay, WST-8 assay and ATP content in primary cultured hepatocytes, Fujimoto et all. reported that SOD2 Knockout mice were useful as an animal model of liver injury or mitochondrial toxicity. see more

T. Fukami, A. Iida, K. Konishi, M. Nakajima , “Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity”, Biochem. Pharmacol.., 2016, doi:10.1016/j.jphs.2016.07.007.