Description:

Technozym®ADAMTS-13ELISAisaFluorogenicELISAkitforthedeterminationofADAMTS-13activityandantigenconcentrationinhumanplasma.ADAMTS-13istheenzymethatcleavesvWFunderlaminarflowconditions.AfunctionaldefectofthisenzymeleadstothepresenceofhighermolecularweightformsofvWFandthustoincreasedplateletaggregation,mainlyinthemicrovasculature.

KitComposition:

• ELISAteststrips(1×6for48T),with8wellseach,coatedwithamonoclonalantiADAMTS13,directedagainsttheCUBdomain;thedryingagentissuppliedinanaluminiumbag.
• Washingbufferconcentrate(PBS;pH7.3);containingdetergent;0.01%merthiolate;1vial,100mL.
• Incubationbuffer(PBS;pH7.3);containsstABIliserprotein;0.01%merthiolate;anddye,1vial,100mL,readyforuse.
• Calibrators(standards)numberedfrom1to5;lyophilised;1vialeach;0.5mL.Concentrationsarelot-specific;consultthelabelonthevialortheincludedbatchtable.
• Highandlowcontrolplasma;lyophilised;1vialeach;0.5mL.Concentrationsarelot-specific;consultthelabelonthevial.
• Activitysubstrate;1vialfor48T;3mLeach,lyophilised.
• Conjugate:anti-ADAMTS-13POX;dyedblue;1vial,0.3mL.
• Antigensubstrate:1vial,6mL.
• Stableperoxidesolution;1vial,0.7mL.
• Stopsolutionforantigensubstrate:1vial;6mL;readytouse.
• Adhesivefilm:forELISAteststrips;2pieces.

Advantages:

• AllowsdeterminationofADAMTS-13activitybelow5%
• Ready-to-usecoatedELISAplate
• Easytousein-houseassaycanleadtosignificantcostsavings
• Plate-basedassaywithcommonlyusedfluorescentADAMTS-13activitysubstrate
• Lessinterferencescomparedtosolution-basedfluorescentassays
• Calibratorsandcontrolsincluded
• Sampleusedundiluted
• Bothactivityandantigenlevelsinoneassay
• Excelevaluationsoftwareavailable

AssayPrinciple:

Background:

ADAMTS-13

ADAMTS-13(adisintegrin-likeandmetalloproteinasewiththrombospondintype1motif13)isanenzyme(vWF-cleavingproteaseorvWF-CP)thatspecificallycleavesvonWillebrandFactor(vWF)multimers.

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